CAJ | 학술논문

目的：探讨眼镜蛇毒对成年大鼠脊神经节脑源性神经营养因子（ BDNF）和c-jun表达的影响。方法：大鼠24只随机分为正常对照组、生理盐水组和眼镜蛇毒组，每组8只。用免疫组织化学的方法，观察在各组大鼠脊神经节BDNF和c-jun的表达。结果：大鼠脊神经节BDNF和c-jun眼镜蛇毒组细胞平均灰度值低于正常对照组和生理盐水组（P＜0．01），且阳性神经元眼镜蛇毒组多于正常对照组和生理盐水组（P＜0．01）。结论：眼镜蛇毒能上调脊神经节BDNF和c-jun的表达，这种表达增加可能与脊神经节损伤的代偿性修复有关。
목적：탐토안경사독대성년대서척신경절뇌원성신경영양인자（ BDNF）화c-jun표체적영향。방법：대서24지수궤분위정상대조조、생리염수조화안경사독조，매조8지。용면역조직화학적방법，관찰재각조대서척신경절BDNF화c-jun적표체。결과：대서척신경절BDNF화c-jun안경사독조세포평균회도치저우정상대조조화생리염수조（P＜0．01），차양성신경원안경사독조다우정상대조조화생리염수조（P＜0．01）。결론：안경사독능상조척신경절BDNF화c-jun적표체，저충표체증가가능여척신경절손상적대상성수복유관。
Objective:To investigate the effects of Naja naja atra( N.naja,Chinese cobra) venom on the expression of brain-derived neurotrophic factor (BDNF) and c-jun in spinal ganglion of adult rats.Methods: Twenty-four adults rats were randomized into control group,saline administration group and N.naja venom treatment group( n=8 for each) .Immunohistochemistry technique was used to detect the expression of BDNF and c-jun in spinal ganglion in each group of rats.Results: The mean gray value of BDNF and c-jun in spinal ganglion was significantly lower in N .najia treatment group than that of saline administration group and control group (P<0.01),and the number of BDNF and c-jun positive cells were also greater than the latter two group(P<0.01).Conclusion: N.naja venom can significantly increase the BDNF and c-jun expression in spinal ganglion of rats,and this mechanism may be as-sociated with compensatory healing of spinal ganglion injury .