CAJ | 학술논문

γ-氨基丁酸（γ-aminobutyric acid，GABA）是哺乳动物中枢神经系统中主要的抑制性神经递质，与焦虑、抑郁、精神分裂等多种神经和精神疾病有关。近年来，越来越多的研究提示，抑郁症的发生与中枢GABA功能缺陷密切相关。但目前基于单胺类递质失调及谷氨酸能神经的研究较多，而对GABA的研究相对较少且比较分散。本文主要通过介绍GABA受体及其作用，以及GABA与5-羟色胺（5-hydroxytryptamine，5-HT）、多巴胺（dopamine，DA）和谷氨酸（glutamic acid，Glu）的相互作用，讨论GABA与抑郁症发生的关系，以期为抑郁症的发生机制与治疗的深入研究提供思路。
γ-안기정산（γ-aminobutyric acid，GABA）시포유동물중추신경계통중주요적억제성신경체질，여초필、억욱、정신분렬등다충신경화정신질병유관。근년래，월래월다적연구제시，억욱증적발생여중추GABA공능결함밀절상관。단목전기우단알류체질실조급곡안산능신경적연구교다，이대GABA적연구상대교소차비교분산。본문주요통과개소GABA수체급기작용，이급GABA여5-간색알（5-hydroxytryptamine，5-HT）、다파알（dopamine，DA）화곡안산（glutamic acid，Glu）적상호작용，토론GABA여억욱증발생적관계，이기위억욱증적발생궤제여치료적심입연구제공사로。
γ-aminobutyric acid (GABA)is the major inhibitory neurotransmitter of the central nervous system (CNS)in mammalian,which involved in several mood disorders such as anxiety,depression and schizophrenia.Nowadays,there are growing evidences showed that the depression is concerned with a de-ficiency in brain GABA.However,there are numerous studies based on the monoamine hypothesis and glutamatergic dysfunction,while the study on GABA is relatively less and scattered.Our aim is to discuss the relationship between depression and GABA by introducing the role of GABA receptors and the interac-tion between GABA and 5-hydroxytryptamine,dopamine and glutamic acid.It provides new ideas for fur-ther study on the pathogenesis and therapy of depression.