CAJ | 학술논문

衰老表现在机体多方面的变化，从各种组织器官的功能障碍，到细胞内结构变化。近年来，关于衰老与内皮细胞损伤的研究越来越受到关注。衰老机体中内皮细胞通过多种途径导致自身结构功能发生一系列改变，最终使其损伤。本文综述了衰老机体中，内皮细胞功能发生的变化，着重讨论衰老机体中诱导内皮细胞损伤的多种通路的作用机制，同时论述了作用于各通路的相关调节因子，为延缓衰老机体内皮损伤提供可能的策略。
쇠로표현재궤체다방면적변화，종각충조직기관적공능장애，도세포내결구변화。근년래，관우쇠로여내피세포손상적연구월래월수도관주。쇠로궤체중내피세포통과다충도경도치자신결구공능발생일계렬개변，최종사기손상。본문종술료쇠로궤체중，내피세포공능발생적변화，착중토론쇠로궤체중유도내피세포손상적다충통로적작용궤제，동시논술료작용우각통로적상관조절인자，위연완쇠로궤체내피손상제공가능적책략。
Aging includes various changes,from the dysfunction of different organs to cellular damages. Recent years,there is a growing attention on the relationship between aging and endothelial cell damage. Aging bodies'endothelial cells are damaged through many ways,all contribute to structural and functional changes.And these pathways are being researched more and more deeply.This paper reviews the change of aging organism and the effects on endothelial cells,focuses on the different pathways on endothelial damage,and also discusses the relevant regulatory factors,which can be treated as new direction for in-hibiting endothelial damages and provide relevant strategies for delaying damages.