CAJ | 학술논문

目的：比较盐酸羟考酮缓释片（奥施康定）与曲马多缓释片（奇曼丁）治疗中度癌痛的近期疗效。方法将100例伴有中度癌痛患者随机分为奥施康定组和奇曼丁组，每组50例，分别接受奥施康定和奇曼丁的治疗。结果奥施康定组治疗后第3、7、10天的NRS评分均较奇曼丁组低，且奥施康定组治疗后第3天NRS评分下降幅度较奇曼丁组明显（ P﹤0.05）；奥施康定组的CR率和有效率分别为34.0%和100.0%，明显高于奇曼丁组的10.0%和84.0%（P﹤0.05）；2组毒副反应发生率比较差异均无统计学意义（P﹥0.05）。结论与奇曼丁相比，应用奥施康定治疗中度癌痛患者，能更快更有效缓解疼痛，而未增加毒副反应。
목적：비교염산간고동완석편（오시강정）여곡마다완석편（기만정）치료중도암통적근기료효。방법장100례반유중도암통환자수궤분위오시강정조화기만정조，매조50례，분별접수오시강정화기만정적치료。결과오시강정조치료후제3、7、10천적NRS평분균교기만정조저，차오시강정조치료후제3천NRS평분하강폭도교기만정조명현（ P﹤0.05）；오시강정조적CR솔화유효솔분별위34.0%화100.0%，명현고우기만정조적10.0%화84.0%（P﹤0.05）；2조독부반응발생솔비교차이균무통계학의의（P﹥0.05）。결론여기만정상비，응용오시강정치료중도암통환자，능경쾌경유효완해동통，이미증가독부반응。
Objective To compare the efficacy and tolerability of oxycodone hydrochloride controlled-release tab-lets( oxycodone)and tramadol hydrochloride sustained-release tablets( tramadol)in the treatment of patients with moderate cancer pain. Methods A total of 100 patients with moderate cancer pain were randomly divided into two groups,50 patients of the oxycodone group was treated with oxycodone,and 50 patients of the tramadol group was treated with tramadol. Results The NRS scorce in the oxy-codone group had declined more significantly than the tramadol group,and the decrease was statistically significant in the first three days (P﹤0. 05). The CR rate and the response rate in the oxycodone group were significantly better than those of the tramadol group (34.0% vs10.0% and100.0% vs84.0%)(P﹤0.05).There was no statistic significant difference in the toxicity incidences be-tween the two groups(P﹥0. 05). Conclusion Compared with tramadol,oxycodone is faster and more effective to relieve pain,and don’t increase the toxicities.