CAJ | 학술논문

目的：探讨男性乳腺神经内分泌癌的临床病理及免疫组化特征。方法分析2例男性乳腺神经内分泌癌临床特点，观察其组织病理形态及免疫表型，并结合文献进行复习。结果年龄56岁、60岁，临床表现为乳腺肿块。肿瘤细胞圆形、卵圆形或梭形，中等大小，排列成梁状、巢片状，梭形细胞排列成栅栏状、流水状，偶见菊形团结构。免疫组化染色结果：Syn、CgA、NSE、34BE12、CK5/6、E-Cadherin弥漫（+）；例1 CD57弥漫（+）；例2 CD56弥漫（+）、ER、PR（++），GCDFP-15、PS2部分（+）。结论男性乳腺神经内分泌癌临床罕见，易发于老年人，依据肿瘤细胞形态特点，结合免疫表型可确诊。
목적：탐토남성유선신경내분비암적림상병리급면역조화특정。방법분석2례남성유선신경내분비암림상특점，관찰기조직병리형태급면역표형，병결합문헌진행복습。결과년령56세、60세，림상표현위유선종괴。종류세포원형、란원형혹사형，중등대소，배렬성량상、소편상，사형세포배렬성책란상、류수상，우견국형단결구。면역조화염색결과：Syn、CgA、NSE、34BE12、CK5/6、E-Cadherin미만（+）；례1 CD57미만（+）；례2 CD56미만（+）、ER、PR（++），GCDFP-15、PS2부분（+）。결론남성유선신경내분비암림상한견，역발우노년인，의거종류세포형태특점，결합면역표형가학진。
Objective To investigate the clinical pathology and immunohistochemical features of male neuroen-docrine breast cancer. Methods The histopathological features and immune phenotype were observed in two cases of male neuroendocrine breast cancer,and the related literature was reviewed. Results Age:56 and 60-year-old,the clinical manifestations:breast lumps. Tumor cells round,oval or spindle-shaped,medium size,arranged with trabecu-lar or nest Flake,spindle-shaped cells arranged in the fence or with water,chrysanthemum-shaped structure of corpo-rations were occasionally observed. Immune phenotype:Syn,CgA,NSE,34ΒE12,CK5,E-Cadherin diffusedly( +);diffusedly CD57( +)in example 1;CD56 diffusedly( +),ER and PR( ++),GCDFP-15 and PS2 Some( +)in example 2. Conclusion Male breast neuroendocrine cancer is rare and could be observed basing on morphological characteristics and immune phenotype.