CAJ | 학술논문

目的：探讨中药配合低剂量化疗药物经肝动脉化疗栓塞术（TACE）治疗中晚期原发性肝癌的临床疗效和毒副反应。方法中晚期肝癌患者57例随机分为治疗组（29例）和对照组（28例）。治疗组给予中药联合低剂量化疗药物TACE，对照组仅给予常规剂量化疗药物TACE。比较观察2组的临床疗效和毒副反应。结果2组瘤体有效率比较差异无统计学意义（P﹥0.05）；2组患者中医证候改善的疗效比较差异有统计学意义（P﹤0.05）；2组AFP控制有效率比较差异有统计学意义（P﹤0.05）；2组在肝肾功能及白细胞变化方面比较差异有统计学意义（P﹤0.05）；2组恶心呕吐、乏力、肝区疼痛发生率比较均有统计学意义（P均﹤0.05）；2组患者整体生活质量比较差异有统计学意义（P﹤0.05）。结论中药配合低剂量化疗药物TACE治疗中晚期肝癌能明显较单纯TACE提高患者生活质量及对治疗的耐受性。
목적：탐토중약배합저제양화료약물경간동맥화료전새술（TACE）치료중만기원발성간암적림상료효화독부반응。방법중만기간암환자57례수궤분위치료조（29례）화대조조（28례）。치료조급여중약연합저제양화료약물TACE，대조조부급여상규제양화료약물TACE。비교관찰2조적림상료효화독부반응。결과2조류체유효솔비교차이무통계학의의（P﹥0.05）；2조환자중의증후개선적료효비교차이유통계학의의（P﹤0.05）；2조AFP공제유효솔비교차이유통계학의의（P﹤0.05）；2조재간신공능급백세포변화방면비교차이유통계학의의（P﹤0.05）；2조악심구토、핍력、간구동통발생솔비교균유통계학의의（P균﹤0.05）；2조환자정체생활질량비교차이유통계학의의（P﹤0.05）。결론중약배합저제양화료약물TACE치료중만기간암능명현교단순TACE제고환자생활질량급대치료적내수성。
Objective To investigate the clinical effect and toxicities of transcatheter arterial chemoembolization ( TACE)with low-dose chemotherapy drugs combined with traditional Chinese drug for advanced liver cancer. Methods Fifty-seven patients with advanced liver cancer were divided into the two groups,29 patients of the treat-ment group received the TACE with low-dose chemotherapy drugs combined with traditional Chinese drug,28 pa-tients of the control group received the TACE with normal-dose chemotherapy drugs,and the efficacy and toxicities were observed. Results There was no statistical difference in the effectiveness rate of tumor size between the two groups(P﹤0. 05). There were statistical differences in the effectiveness rate of syndromes of TCM between the two groups(P﹤0. 05). There were statistical differences in the AFP control rate between the two groups(P﹤0. 05). There were statistical differences in the liver function,renal function and leucocyte counts between the two groups (P﹤0. 05). There were statistical differences in the nausea and vomitting,anergy and hepatalgia between the two groups(P﹤0. 05). There were statistical differences in the quality of life between the two groups(P﹤0. 05). Con-clusion Compared with pure TACE method,TACE with low-dose chemotherapy drugs combined with traditional Chinese drug can improve the quality of life and the tolerance.