CAJ | 학술논문

目的：探讨放疗联合周剂量紫杉醇治疗老年食管癌的疗效及毒副反应。方法49例老年食管癌患者随机分为同步放化疗组（24例）和单纯放疗组（25例），2组放疗均采用常规分割，照射剂量60~66 Gy。同步放化疗组紫杉醇60 mg，每周1次，连续6周。结果同步放化疗组有效率87.5%，高于单纯放疗组的60.0%（P﹤0.05）。同步放化疗组Ⅱ、Ⅲ度白细胞减少占54.2%，明显高于单纯放疗组的20.0%（P ﹤0.05）。结论放疗联合周剂量紫杉醇治疗老年食管癌近期疗效较好，毒副反应相对加重但可耐受。
목적：탐토방료연합주제량자삼순치료노년식관암적료효급독부반응。방법49례노년식관암환자수궤분위동보방화료조（24례）화단순방료조（25례），2조방료균채용상규분할，조사제량60~66 Gy。동보방화료조자삼순60 mg，매주1차，련속6주。결과동보방화료조유효솔87.5%，고우단순방료조적60.0%（P﹤0.05）。동보방화료조Ⅱ、Ⅲ도백세포감소점54.2%，명현고우단순방료조적20.0%（P ﹤0.05）。결론방료연합주제량자삼순치료노년식관암근기료효교호，독부반응상대가중단가내수。
Objective To evaluate the efficacy and toxicities of weekly dose paclitaxel combined with radiothera-py for elderly patients with esophageal carcinoma. Methods Forty-nine elderly patients with esophageal carcinoma were randomly divided into two groups,24 patients of the concurrent chemotherapy and radiotherapy group received the 60-66 Gy of routine radiotherapy plus weekly dose paclitaxel,60 mg of paclitaxel was administered once a week for 6 successive weeks starting from the first day of radiotherapy,and 25 patients of the radiotherapy group received the 60-66 Gy of routine radiotherapy. Results The response rate of the concurrent chemotherapy and radiotherapy group was 87. 5%,and was 60. 0% in the radiotherapy group(P﹤0. 05). The occurrence rate of leucopenia with grade Ⅱ or Ⅲ was 54. 2% in the concurrent chemotherapy and radiotherapy group,and was 20. 0% in the radio-therapy group(P﹤0. 05). Conclusion Weekly dose paclitaxel combined with radiotherapy is effective for the eld-erly patients with esophageal carcinoma,and the toxicities can be tolerated.