CAJ | 학술논문

目的：检测转录因子E2F1在乳腺浸润性导管癌（ IDC）组织中的表达及其在IDC发生、发展中的作用。方法采用免疫组化S-P法检测91例乳腺 IDC组织、18例不典型增生组织、30例正常乳腺组织中E2F1蛋白表达情况。结果91例乳腺IDC组织、18例不典型增生组织及30例正常乳腺组织中E2F1蛋白阳性表达率分别为47.3%（43/91）、11.1%（2/18）和0.0%（0/30），差异有统计学意义（P﹤0.05）。IDC组织中E2F1蛋白表达与腋窝淋巴结转移、肿瘤大小、组织学分级、TNM分期及ER、PR状态有关（ P﹤0.05）。结论 E2F1在IDC组织中高表达，可能是参与乳腺IDC病程进展的重要因子，可作为预测乳腺IDC淋巴结转移及预后评估的指标。
목적：검측전록인자E2F1재유선침윤성도관암（ IDC）조직중적표체급기재IDC발생、발전중적작용。방법채용면역조화S-P법검측91례유선 IDC조직、18례불전형증생조직、30례정상유선조직중E2F1단백표체정황。결과91례유선IDC조직、18례불전형증생조직급30례정상유선조직중E2F1단백양성표체솔분별위47.3%（43/91）、11.1%（2/18）화0.0%（0/30），차이유통계학의의（P﹤0.05）。IDC조직중E2F1단백표체여액와림파결전이、종류대소、조직학분급、TNM분기급ER、PR상태유관（ P﹤0.05）。결론 E2F1재IDC조직중고표체，가능시삼여유선IDC병정진전적중요인자，가작위예측유선IDC림파결전이급예후평고적지표。
Objective To evaluate the expression of E2F1 protein and the correlations with carcinogenesis and progression in breast invasive dutcal carcinoma( IDC). Methods The immunohistochemical S-P method was used to detect the expression of E2F1 in the 91 cases of breast IDC,18 cases of atypical hyperplasia and 30 cases of nor-mal breast tissues. Results There were statistical differences in the positive rate of E2F1 among the breast IDC [47. 3%(43/91)],the atypical hyperplasia[11. 1%(2/18)]and the normal breast tissues[0. 0%(0/30)](P﹤0. 05). The expression of E2F1 was correlated with lymph node metastasis,tumor size,histological grading,TNM tumor stage,ER and PR status(P﹤0. 05). Conclusion E2F1 is up-regulated in the breast IDC,and is associated with the progression of breast IDC,E2F1 might be a novel molecular marker to predict lymph node metastasis and prognosis of breast IDC.