北京生物医学工程
北京生物醫學工程
북경생물의학공정
BEIJING BIOMEDICAL ENGINEERING
2014年
3期
228-233
,共6页
阿尔茨海默病%轻度认知障碍%VBM-DARTEL%大脑灰质
阿爾茨海默病%輕度認知障礙%VBM-DARTEL%大腦灰質
아이자해묵병%경도인지장애%VBM-DARTEL%대뇌회질
Alzheimer disease%mild cognitive impairment%VBM-DARTEL%grey matter
探究阿尔茨海默病（Alzheimer disease，AD ）与轻度认知障碍（mild cognitive impairment，MCI）大脑灰质萎缩的特征，为AD的演化机制探索提供一种有意义的检测方法。方法基于体素形态学（voxel based morphometry，VBM）结合通过取幂李代数的微分同胚解剖配准（diffeomorphic anatomical registration through exponentiated lie algebra，DARTEL）方法，首先预处理了58例正常人（normal control，NC）、26例进展型 MCI（progressive MCI，PMCI）患者、46例稳定型 MCI（stable MCI， SMCI）患者和40例 AD 患者的 T1结构磁共振图像（magnetic resonance imaging，MRI ）数据，利用DARTEL的方法创建特异性模板，再利用变形场将三组灰质图像配准到 MNI 空间并通过调制以保证体素的总数量不变。最后采用双样本 t检验对 MNI 空间平滑后的图像数据进行统计学分析（P≤0.005，未校正）。结果相对于 NC 组，AD患者主要在双侧颞叶、双侧海马及海马旁回、双侧杏仁核、双侧脑岛、左侧枕中回、左侧楔前叶、左侧后扣带回存在严重萎缩。MCI患者大脑灰质的萎缩区域主要集中在双侧豆状壳核、左侧杏仁核和左侧海马区域。PMCI患者大脑萎缩区域主要分布在左侧杏仁核、左侧海马和左侧豆状壳核，而 SMCI患者大脑灰质未见显著萎缩。相对于 MCI，AD 患者在双侧颞叶、双侧海马、双侧楔前叶、双侧额中回、左侧后扣带回、左侧脑岛、右侧杏仁核、右侧海马旁回、右侧顶上回存在严重萎缩。相对于 AD，未发现 MCI患者大脑灰质出现明显萎缩区域。相对于 SMCI，PMCI 主要表现在左侧颞下回出现显著萎缩，而相对 PMCI，SMCI未发现显著萎缩。结论利用 VBM-DARTEL方法可实现 MRI 图像的精确配准以检测大脑灰质体积的微小改变，为 AD早期诊断提供可靠的影像学特征依据。
探究阿爾茨海默病（Alzheimer disease，AD ）與輕度認知障礙（mild cognitive impairment，MCI）大腦灰質萎縮的特徵，為AD的縯化機製探索提供一種有意義的檢測方法。方法基于體素形態學（voxel based morphometry，VBM）結閤通過取冪李代數的微分同胚解剖配準（diffeomorphic anatomical registration through exponentiated lie algebra，DARTEL）方法，首先預處理瞭58例正常人（normal control，NC）、26例進展型 MCI（progressive MCI，PMCI）患者、46例穩定型 MCI（stable MCI， SMCI）患者和40例 AD 患者的 T1結構磁共振圖像（magnetic resonance imaging，MRI ）數據，利用DARTEL的方法創建特異性模闆，再利用變形場將三組灰質圖像配準到 MNI 空間併通過調製以保證體素的總數量不變。最後採用雙樣本 t檢驗對 MNI 空間平滑後的圖像數據進行統計學分析（P≤0.005，未校正）。結果相對于 NC 組，AD患者主要在雙側顳葉、雙側海馬及海馬徬迴、雙側杏仁覈、雙側腦島、左側枕中迴、左側楔前葉、左側後釦帶迴存在嚴重萎縮。MCI患者大腦灰質的萎縮區域主要集中在雙側豆狀殼覈、左側杏仁覈和左側海馬區域。PMCI患者大腦萎縮區域主要分佈在左側杏仁覈、左側海馬和左側豆狀殼覈，而 SMCI患者大腦灰質未見顯著萎縮。相對于 MCI，AD 患者在雙側顳葉、雙側海馬、雙側楔前葉、雙側額中迴、左側後釦帶迴、左側腦島、右側杏仁覈、右側海馬徬迴、右側頂上迴存在嚴重萎縮。相對于 AD，未髮現 MCI患者大腦灰質齣現明顯萎縮區域。相對于 SMCI，PMCI 主要錶現在左側顳下迴齣現顯著萎縮，而相對 PMCI，SMCI未髮現顯著萎縮。結論利用 VBM-DARTEL方法可實現 MRI 圖像的精確配準以檢測大腦灰質體積的微小改變，為 AD早期診斷提供可靠的影像學特徵依據。
탐구아이자해묵병（Alzheimer disease，AD ）여경도인지장애（mild cognitive impairment，MCI）대뇌회질위축적특정，위AD적연화궤제탐색제공일충유의의적검측방법。방법기우체소형태학（voxel based morphometry，VBM）결합통과취멱리대수적미분동배해부배준（diffeomorphic anatomical registration through exponentiated lie algebra，DARTEL）방법，수선예처리료58례정상인（normal control，NC）、26례진전형 MCI（progressive MCI，PMCI）환자、46례은정형 MCI（stable MCI， SMCI）환자화40례 AD 환자적 T1결구자공진도상（magnetic resonance imaging，MRI ）수거，이용DARTEL적방법창건특이성모판，재이용변형장장삼조회질도상배준도 MNI 공간병통과조제이보증체소적총수량불변。최후채용쌍양본 t검험대 MNI 공간평활후적도상수거진행통계학분석（P≤0.005，미교정）。결과상대우 NC 조，AD환자주요재쌍측섭협、쌍측해마급해마방회、쌍측행인핵、쌍측뇌도、좌측침중회、좌측설전협、좌측후구대회존재엄중위축。MCI환자대뇌회질적위축구역주요집중재쌍측두상각핵、좌측행인핵화좌측해마구역。PMCI환자대뇌위축구역주요분포재좌측행인핵、좌측해마화좌측두상각핵，이 SMCI환자대뇌회질미견현저위축。상대우 MCI，AD 환자재쌍측섭협、쌍측해마、쌍측설전협、쌍측액중회、좌측후구대회、좌측뇌도、우측행인핵、우측해마방회、우측정상회존재엄중위축。상대우 AD，미발현 MCI환자대뇌회질출현명현위축구역。상대우 SMCI，PMCI 주요표현재좌측섭하회출현현저위축，이상대 PMCI，SMCI미발현현저위축。결론이용 VBM-DARTEL방법가실현 MRI 도상적정학배준이검측대뇌회질체적적미소개변，위 AD조기진단제공가고적영상학특정의거。
Objective To investigate the brain grey matter atrophy in Alzheimer disease (AD)and mild cognitive impairment (MCI ), and provide a detective method for exploring the evolution mechanism of AD.Methods By combining voxel based morphometry (VBM) and diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL),we firstly register and segment three T1 structural MRI datasets of 58 normal control (NC),40 AD patients,72 MCI patients including 26 progressive MCI (PMCI)patients and 46 stable MCI (SMCI ) patients.Then a specific template is built by using DARTEL method.Through deformation fields,the grey matter images are registered to MNI space with preserving the total amount of voxels by applying modulation method.Finally,statistical analysis is made on the processed datasets with two sample t test (P≤0.005,uncorrected).Results Compared to NC,the
<br> atrophy regions in AD mainly locate in the bilateral temporal lobe, the bilateral hippocampus and parahippocampal gyrus,the bilateral amygdala,the bilateral insula,the left middle occipital gyrus,the left precuneus,the left posterior cingulate gyrus.The atrophy regions in MCI locate in the bilateral putamen,the left amygdale and the left hippocampus.The atrophy regions in PMCI locate in the left putamen,the left amygdala and the left hippocampus.There is no atrophy region found in SMCI. Compared to MCI,the atrophy regions in AD are the bilateral temporal lobe,the bilateral hippocampus,the bilateral precuneus,the bilateral middle frontal gyrus,the left cingulate gyrus,the left insula,the right amygdala,the right parahippocampal gyrus,the right superior parietal gyrus.There is no atrophy region in MCI compared to AD. Compared to SMCI, the atrophy region in PMCI is in left inferior temporal gyrus,yet there is no atrophy region found in SMCI compared to PMCI. Conclusions VBM-DARTEL based method can achieve a more accurate registration of MRI images and detect subtle volume changes of cerebral grey matter,which is helpful in providing reliable radiology evidence for the early AD diagnosis.
