中西医结合心血管病电子杂志
中西醫結閤心血管病電子雜誌
중서의결합심혈관병전자잡지
Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine (Electronic)
2014年
4期
25-27
,共3页
老年高脂血症%长期%松龄血脉康%辛伐他汀%安全%有效
老年高脂血癥%長期%鬆齡血脈康%辛伐他汀%安全%有效
노년고지혈증%장기%송령혈맥강%신벌타정%안전%유효
Elderly Patients with Hyperlipidemia%Long -term%Songlingxuemaikang%Simvastatin%Safety%Efficacy
目的:探讨长期使用松龄血脉康和辛伐他汀联合治疗老年高脂血症患者的效果和安全性。方法选择我院≥60岁的老年血脂异常患者189例,均服用松龄血脉康胶囊和/或辛伐他汀2年以上。服用松龄血脉康和辛伐他汀患者99例(治疗组),服用辛伐他汀患者90例(对照组)。收集两组患者的相关病史及给药前、用药1年及2年后的肝、肾功能、血脂、肌酸激酶指标,观察检查结果及不良反应,比较两组疗效及安全性。结果治疗组治疗1年及2年后较治疗前比,总胆固醇、甘油三酯及低密度脂蛋白胆固醇(LDL -C)、高密度脂蛋白胆固醇(HDL -C)(P <0.05或 P <0.01)差异有统计学意义;对照组治疗1年及2年后较治疗前比,总胆固醇、低密度脂蛋白胆固醇(LDL -C)差异有统计学意义(P <0.05或 P <0.01),甘油三酯及高密度脂蛋白胆固醇(HDL -C)差异均无统计学意义(P >0.05);治疗组与对照组两组比较总胆固醇、甘油三酯及低密度脂蛋白胆固醇(LDL -C)、高密度脂蛋白胆固醇(HDL -C)差异有统计学意义(P <0.05或 P <0.01);两组比较治疗1年及2年后空腹血糖、谷丙转氨酶、肌酸激酶、肌酐,差异无统计学意义 P >0.05)。结论长期使用松龄血脉康和辛伐他汀联合治疗老年高脂血症患者是安全、且疗效优于单独应用辛伐他汀。
目的:探討長期使用鬆齡血脈康和辛伐他汀聯閤治療老年高脂血癥患者的效果和安全性。方法選擇我院≥60歲的老年血脂異常患者189例,均服用鬆齡血脈康膠囊和/或辛伐他汀2年以上。服用鬆齡血脈康和辛伐他汀患者99例(治療組),服用辛伐他汀患者90例(對照組)。收集兩組患者的相關病史及給藥前、用藥1年及2年後的肝、腎功能、血脂、肌痠激酶指標,觀察檢查結果及不良反應,比較兩組療效及安全性。結果治療組治療1年及2年後較治療前比,總膽固醇、甘油三酯及低密度脂蛋白膽固醇(LDL -C)、高密度脂蛋白膽固醇(HDL -C)(P <0.05或 P <0.01)差異有統計學意義;對照組治療1年及2年後較治療前比,總膽固醇、低密度脂蛋白膽固醇(LDL -C)差異有統計學意義(P <0.05或 P <0.01),甘油三酯及高密度脂蛋白膽固醇(HDL -C)差異均無統計學意義(P >0.05);治療組與對照組兩組比較總膽固醇、甘油三酯及低密度脂蛋白膽固醇(LDL -C)、高密度脂蛋白膽固醇(HDL -C)差異有統計學意義(P <0.05或 P <0.01);兩組比較治療1年及2年後空腹血糖、穀丙轉氨酶、肌痠激酶、肌酐,差異無統計學意義 P >0.05)。結論長期使用鬆齡血脈康和辛伐他汀聯閤治療老年高脂血癥患者是安全、且療效優于單獨應用辛伐他汀。
목적:탐토장기사용송령혈맥강화신벌타정연합치료노년고지혈증환자적효과화안전성。방법선택아원≥60세적노년혈지이상환자189례,균복용송령혈맥강효낭화/혹신벌타정2년이상。복용송령혈맥강화신벌타정환자99례(치료조),복용신벌타정환자90례(대조조)。수집량조환자적상관병사급급약전、용약1년급2년후적간、신공능、혈지、기산격매지표,관찰검사결과급불량반응,비교량조료효급안전성。결과치료조치료1년급2년후교치료전비,총담고순、감유삼지급저밀도지단백담고순(LDL -C)、고밀도지단백담고순(HDL -C)(P <0.05혹 P <0.01)차이유통계학의의;대조조치료1년급2년후교치료전비,총담고순、저밀도지단백담고순(LDL -C)차이유통계학의의(P <0.05혹 P <0.01),감유삼지급고밀도지단백담고순(HDL -C)차이균무통계학의의(P >0.05);치료조여대조조량조비교총담고순、감유삼지급저밀도지단백담고순(LDL -C)、고밀도지단백담고순(HDL -C)차이유통계학의의(P <0.05혹 P <0.01);량조비교치료1년급2년후공복혈당、곡병전안매、기산격매、기항,차이무통계학의의 P >0.05)。결론장기사용송령혈맥강화신벌타정연합치료노년고지혈증환자시안전、차료효우우단독응용신벌타정。
Objective To assess the effect and safety of Songlingxuemaikang and Simvastatin combination in a long run treatment of elderly patients with hyperlipidemia.Methods Choose 189 elderly patients,aged over 60,with dyslipidemia,from our Institute and all have been taking Songlingxuemaikang capsules and or Simvastatin for more than 2 years.Patients were divided into two groups,Treatment Group(99 cases,taking both Songlingxuemaikang and Simvastatin)and Control Group(90 cases,taking Simvastatin only).Relevant medical history of the two Groups and respective indicating data of liver renal function,blood lipids, creatine kinase index were collected prior,one -year and two -year after treatment.Examination results as well as adverse reactions were also observed.At the same time,the medical curative effect and its safety were compared between the two Groups.Results For Treatment Group,comparing data of 1 -year and 2 -year after treatment with those prior treatment,differences in total cholesterol,triglyceride and low density lipoprotein cholesterol(LDL -C)and high density lipo-protein cholesterol(HDL -C)showed statistical significance(P <0.05 or P <0.01).For Control Group,with the same comparison,differences in total cholesterol and low density lipoprotein cholesterol(LDL -C)indicated statistical significance(P <0.05 or P <0.01)while differences of Triglyceride and high density lipo-protein cholesterol(HDL -C)had no statistical significance(P >0.05).Comparing Treatment Group to Control Group,differences in total cholesterol,triglyceride and low density lipoprotein cholesterol(LDL -C)and high density lipoprotein cholesterol(HDL -C)had statistical significance(P <0.05 or P <0.01).For both Groups aforementioned,with the comparison of 1 -year and 2 -year treatment,the difference shows no statistically significance(P >0.05)in fasting blood glu-cose,alanine aminotransferase,creatine kinase,or creatinine.Conclusion Applying combination of both Songlingxuemaikang capsules and Simvastatin in a long term treatment of elderly patients with hyperlipidemia is demonstrated to be safe,and its therapeutic effect is better than Simvastatin alone.