CAJ | 학술논문

目的：优化非那雄胺分散片的处方及制备工艺，测定其溶出度。方法采用湿法制粒压片，正交试验优化处方工艺。结果非那雄胺片的处方组成：稀释剂为40％微晶纤维素和50％乳糖，崩解剂为5％低取代羟丙基纤维素，黏合剂为5％聚维酮K 3025％的乙醇溶液，包衣液为15％的85G型欧巴代，45 min时溶出度可达90％以上。结论自制非那雄胺片质量稳定，工艺可靠，适合工业化生产要求。
목적：우화비나웅알분산편적처방급제비공예，측정기용출도。방법채용습법제립압편，정교시험우화처방공예。결과비나웅알편적처방조성：희석제위40％미정섬유소화50％유당，붕해제위5％저취대간병기섬유소，점합제위5％취유동K 3025％적을순용액，포의액위15％적85G형구파대，45 min시용출도가체90％이상。결론자제비나웅알편질량은정，공예가고，괄합공업화생산요구。
Objective To optimize the prescription and preparation technology of finasteride dispersible tablets .Methods Wet granulation technique was applied to optimize the formulation and technology of finasteride tablets .Results The formulation of fi-nasteride tablets was that microcrystalline cellulose and lactose acts as diluent , 5% of low-substituted hydroxypropyl cellulose acts as disintegrant , 5%of povidone in alcohol water mixture acts as adhesive and 15%of opadry 85 G type acts as coating solution .The per-centage of dissolution was more than 90%in 45 miniutes.Conclusion The self-made finasteride tablets had stable quality , reliable process and were suitable for industrialized mass production .