CAJ | 학술논문

清蛋白（白蛋白）是一种理想的药物载体，但由于其在体内半衰期短以及易被酶降解等缺点限制了其应用，然而根据其具有多个修饰位点的结构特点，可通过PEG修饰延长循环时间，阻碍酶的作用等。目前，PEG修饰清蛋白仍处于研究阶段，已有较多关于PEG修饰清蛋白的研究，例如PEG修饰所起的作用、对清蛋白及其制剂的影响，以及修饰位点的选择等。本文对清蛋白的PEG化修饰的相关研究进行综述。
청단백（백단백）시일충이상적약물재체，단유우기재체내반쇠기단이급역피매강해등결점한제료기응용，연이근거기구유다개수식위점적결구특점，가통과PEG수식연장순배시간，조애매적작용등。목전，PEG수식청단백잉처우연구계단，이유교다관우PEG수식청단백적연구，례여PEG수식소기적작용、대청단백급기제제적영향，이급수식위점적선택등。본문대청단백적PEG화수식적상관연구진행종술。
Albumin is an ideal drug carrier , but its application was limited because of the shortcomings of short half -life and susceptible to enzymatic degradation in vivo .However, according to its structural features , albumin has a plurality of modification sites, which can be modified by PEG modifier to extend the cycle time and obstruct the action of the enzyme .Currently, the PEG-mod-ified albumin is still in the research stage , and there have been many studies about PEG-modified albumin , such as the role of PEG modification , the effects on albumin and its preparations and the modification sites selection .The article reviewed the related studies a-bout the PEGylation of albumin .