CAJ | 학술논문

目的：了解包河区2～12岁儿童A和C群流脑抗体水平，为制定流脑防控策略提供科学依据。方法：选择2011～2013年在包河区疾控中心进行抗体检测的984名儿童作为研究对象，询问儿童基本信息和流脑疫苗既往免疫史，检测儿童A和C群流脑抗体阳性情况。结果：A群和C群流脑抗体阳性率分别为70．3％和87．1％， A群和C群流脑抗体阳性率分布性别、户籍地属性间差异无统计学意义（P＞0．05），而2～5岁儿童A、C群流脑抗体阳性率均高于6～12岁儿童，且差异有统计学意义（P＜0．05），按程序全程接种的儿童（A、C群流脑）抗体阳性率高于未全程接种者，接种2剂次A＋C流脑结合疫苗＋1剂次A＋C流脑多糖疫苗者A群和C群流脑抗体阳性率高于接种2剂次A群流脑多糖疫苗＋1剂次A＋C流脑多糖疫苗。结论：适龄儿童按免疫程序完成2剂次A＋C流脑结合疫苗基础免疫和2剂次A＋C流脑多糖疫苗加强免疫，方能达到最好预防效果。
목적：료해포하구2～12세인동A화C군류뇌항체수평，위제정류뇌방공책략제공과학의거。방법：선택2011～2013년재포하구질공중심진행항체검측적984명인동작위연구대상，순문인동기본신식화류뇌역묘기왕면역사，검측인동A화C군류뇌항체양성정황。결과：A군화C군류뇌항체양성솔분별위70．3％화87．1％， A군화C군류뇌항체양성솔분포성별、호적지속성간차이무통계학의의（P＞0．05），이2～5세인동A、C군류뇌항체양성솔균고우6～12세인동，차차이유통계학의의（P＜0．05），안정서전정접충적인동（A、C군류뇌）항체양성솔고우미전정접충자，접충2제차A＋C류뇌결합역묘＋1제차A＋C류뇌다당역묘자A군화C군류뇌항체양성솔고우접충2제차A군류뇌다당역묘＋1제차A＋C류뇌다당역묘。결론：괄령인동안면역정서완성2제차A＋C류뇌결합역묘기출면역화2제차A＋C류뇌다당역묘가강면역，방능체도최호예방효과。
Objective:To investigate the antibody levels of group A and group C of epidemic cerebrospinal meningitis in children aged two to twelve years living in Baohe area of Hefei city ,China for scientific evidence to plan a strategy in prevention and control of this epidemics .Methods:984 children,under-gone detection of positive antibody against meningococcus in Baohe Center for Disease Control and Prevention between 2011 and 2013,were included.De-mographic information and history of vaccine for epidemic menigitis were investigated ,and the positive antibody against serogroup A and C was maintained . Results:Positive rate of the antibody against serogroup A and C of epidemic cerebrospinal meningitis was 70.3% and 87.1%,respectively,yet remained no statistical difference regarding the genders and census register(P>0.05).Positive rate for serogroup A and C was higher in children aged two to five years than those of six to twelve years,and the difference was significant(P<0.05).Also,the positive rate was higher in children received complete vacci-nation protocol than those failed to,and in those received double doses of serogroup A and C vaccines plus one dose of A and C polysaccharides were higher than children received double doses of serogroup A vaccines plus one dose of A and C polysaccharides .Conclusion:Favorable prevention effects can be a-chieved in children on condition that they are managed with double doses of purified serogroup A and C vaccines for fundamental immunity and additional double doses of A and C polysaccharides.