CAJ | 학술논문

目的：探讨肺挫伤患者血清人克拉拉细胞蛋白（Clara cell protein，CC16）水平变化及临床意义。方法：应用ELISA方法检测42例肺挫伤患者（实验Ⅰ组：轻-中度肺挫伤患者24例；实验Ⅱ组：重度肺挫伤患者18例）伤后24 h内及治疗后1 d、3 d、7 d、14 d血清CC16水平变化，并与16例健康体检者（对照组）血清CC16水平进行比较。结果：实验组各个时间点血清CC16水平均高于对照组，差异具有统计学意义（ P＜0．01）。伤后24 h内和治疗后1 d、3 d、7 d、14 d血清CC16水平之间均有差异（ P＜0．01），且有逐渐下降趋势。实验Ⅱ组各个时间点血清CC16水平均较实验Ⅰ组同时间点偏高，差异有统计学意义（ P＜0．01）。结论：肺挫伤患者伤后早期血清CC16水平明显上升，且随治疗进程逐渐下降。血清CC16水平上升与肺挫伤程度有密切关系。血清CC16水平变化可能为肺挫伤早期诊断提供生物学指标。
목적：탐토폐좌상환자혈청인극랍랍세포단백（Clara cell protein，CC16）수평변화급림상의의。방법：응용ELISA방법검측42례폐좌상환자（실험Ⅰ조：경-중도폐좌상환자24례；실험Ⅱ조：중도폐좌상환자18례）상후24 h내급치료후1 d、3 d、7 d、14 d혈청CC16수평변화，병여16례건강체검자（대조조）혈청CC16수평진행비교。결과：실험조각개시간점혈청CC16수평균고우대조조，차이구유통계학의의（ P＜0．01）。상후24 h내화치료후1 d、3 d、7 d、14 d혈청CC16수평지간균유차이（ P＜0．01），차유축점하강추세。실험Ⅱ조각개시간점혈청CC16수평균교실험Ⅰ조동시간점편고，차이유통계학의의（ P＜0．01）。결론：폐좌상환자상후조기혈청CC16수평명현상승，차수치료진정축점하강。혈청CC16수평상승여폐좌상정도유밀절관계。혈청CC16수평변화가능위폐좌상조기진단제공생물학지표。
Objective:To investigate the variation and clinical significance of 16kDa Clara cell protein(CC16) in patients with pulmonary contusion. Methods:Forty-two patients with pulmonary contusion were divided into experimental group I(n=24,moderate pulmonary contusion)and experimental groupⅡ(n=18,severe pulmonary contusion).Enzyme-linked immunoadsordent assay (ELISA) was used to detect the serum levels of CC16 in the two groups of patients within 24 h after the incident and at day 1,3,7 and 14 after treatment.The results were compared with another 16 healthy subjects in-cluded as controls.Results:Serum CC16 level in each time point was higher in the two experimental groups than the controls(P<0.01).The difference was significant concerning the levels of CC16 measured within 24 h after contusion and at day 1,3,7 and 14 after treatment(P<0.01),yet the levels ten-ded to decline.In addition,the levels in each time point in experimental group II were somewhat higher than group I,with statistical difference(P<0.01). Conclusion:Serum CC16 levels are markedly elevated at the early stage of pulmonary contusion and tend to decrease after treatment .Rise of the CC16 levels are associated with the injury degree,for which measurement of the levels may serve as a biomarker for evaluation of the serious condition of this pul-monary contusion.