皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2014年
4期
308-310
,共3页
两性霉素B%侵袭性真菌感染%血液病
兩性黴素B%侵襲性真菌感染%血液病
량성매소B%침습성진균감염%혈액병
amphotericin B%invasive fungal infection%hematologic diseases
目的：观察国产两性霉素B治疗血液病合并侵袭性真菌感染的有效性及安全性。方法：47例血液病合并真菌感染的患者予国产两性霉素B治疗，剂量为5～30 mg/d，用药时间11～108 d，中位数为23 d，分析侵袭性真菌病的病原菌特点、感染部位、疗效及治疗药物副作用。结果：静脉使用两性霉素B临床总有效率为70．2％。不良反应包括寒战、高热、低钾血症、肝肾功能损害等副作用。结论：只要合理应用，并积极防治其不良反应，两性霉素B仍是较为安全有效的抗真菌药物。
目的：觀察國產兩性黴素B治療血液病閤併侵襲性真菌感染的有效性及安全性。方法：47例血液病閤併真菌感染的患者予國產兩性黴素B治療，劑量為5～30 mg/d，用藥時間11～108 d，中位數為23 d，分析侵襲性真菌病的病原菌特點、感染部位、療效及治療藥物副作用。結果：靜脈使用兩性黴素B臨床總有效率為70．2％。不良反應包括寒戰、高熱、低鉀血癥、肝腎功能損害等副作用。結論：隻要閤理應用，併積極防治其不良反應，兩性黴素B仍是較為安全有效的抗真菌藥物。
목적：관찰국산량성매소B치료혈액병합병침습성진균감염적유효성급안전성。방법：47례혈액병합병진균감염적환자여국산량성매소B치료，제량위5～30 mg/d，용약시간11～108 d，중위수위23 d，분석침습성진균병적병원균특점、감염부위、료효급치료약물부작용。결과：정맥사용량성매소B림상총유효솔위70．2％。불량반응포괄한전、고열、저갑혈증、간신공능손해등부작용。결론：지요합리응용，병적겁방치기불량반응，량성매소B잉시교위안전유효적항진균약물。
Objective:To evaluate the efficacies and side effects of domestic amphotericin B for treatment of patients with hematologic diseases associated with invasive fungal infections(IFI).Methods:Forty-seven patients were treated with domestic amphotericin B in a dose of 5-30 mg/d for consecutive 11 days to 108 days(mean 23 d),and analyzed were the pathogenic bacteria,organs involved,therapeutic efficacy and side effects of invasive fungal diseases. Results:The overall effective rate was 70.2% by intravenous drip.The adverse effects were associated with chill,fever,hypokalaemia,and damage to he-patic and renal function.Conclusion:Domestic amphotericin B can be safe and effective in against IFI,if it is administered rationally and the adverse effects are well managed.
