CAJ | 학술논문

在临床上，肝窦阻塞综合征比较少见，近年来发病率逐年升高。其主要临床表现为顽固性腹水、黄疸、肝肿大。主要病因是摄入含吡咯烷生物碱的中草药或植物。目前早期诊断困难，无特效治疗方法，主要为对症和支持治疗。本文主要介绍摄入含吡咯烷生物碱的中草药导致的肝窦阻塞综合征的发病机制、病理学和临床表现，以及诊断和治疗方面的进展。
재림상상，간두조새종합정비교소견，근년래발병솔축년승고。기주요림상표현위완고성복수、황달、간종대。주요병인시섭입함필각완생물감적중초약혹식물。목전조기진단곤난，무특효치료방법，주요위대증화지지치료。본문주요개소섭입함필각완생물감적중초약도치적간두조새종합정적발병궤제、병이학화림상표현，이급진단화치료방면적진전。
Hepatic sinusoidal obstruction syndrome is rare clinically,but the incidence is recently increased. The clinical manifestations are mainly refractory ascites,jaundice and hepatomegaly.The main causes is the ingestion of pyrrolizidine alka-loids-containing herbs or plants. The early diagnosis is currently difficult. There is no specific therapy for patients with hepatic sinusoidal obstruction syndrome,except for symptomatic and supportive therapy. This review mainly discuss the mechanism,pathol-ogy,early diagnosis,and therapy of this entity.