CAJ | 학술논문

目的研究脑池内注入NC -PLGA缓释微球对脑血管痉挛的治疗作用.方法采用枕大池二次注血法制作兔蛛网膜下腔出血模型.分别采用脑池内注入NC -PLGA微球和尼卡地平的方法治疗脑血管痉挛.应用经颅多普勒技术测基底动脉的血流速度,脑血管造影测量基底动脉直径,光镜和电镜行病理检查,观察基底动脉的形态学变化,评价脑血管痉挛的严重程度.结果脑池内注入NC - PLGA微球和尼卡地平都能降低基底动脉的血流速度(P＜0.01),基底动脉的直径明显升高(P＜0.01),并能明显改善血管壁的病理改变,但前者只需一次性注入后者总量的1/4既可达到同样的疗效.结论经脑池内注入NC -PLGA缓释微球能明显减轻脑血管痉挛的严重程度,并可减轻痉挛血管壁的病理学变化.
목적 연구뇌지내주입NC -PLGA완석미구대뇌혈관경련적치료작용.방법 채용침대지이차주혈법제작토주망막하강출혈모형.분별채용뇌지내주입NC -PLGA미구화니잡지평적방법치료뇌혈관경련.응용경로다보륵기술측기저동맥적혈류속도,뇌혈관조영측량기저동맥직경,광경화전경행병리검사,관찰기저동맥적형태학변화,평개뇌혈관경련적엄중정도.결과 뇌지내주입NC - PLGA미구화니잡지평도능강저기저동맥적혈류속도(P＜0.01),기저동맥적직경명현승고(P＜0.01),병능명현개선혈관벽적병리개변,단전자지수일차성주입후자총량적1/4기가체도동양적료효.결론 경뇌지내주입NC -PLGA완석미구능명현감경뇌혈관경련적엄중정도,병가감경경련혈관벽적병이학변화.
Objective To study the therapeutic effects of intracisternal infusion of( nicardipine,NC) NC - PLGA microspheres solution on rabbits cerebral vasospasm (CVS) models.Method The primary SAH rabbit models were produced by injecting blood two times through cisterna magna.The CVS rabbit models were treated by intracisternal infusing of NC - PLGA microspheres and Nicardipine solution.The basal arteriospasm was observed with transcranial Doppler.The diameter of basilar artery was measured by cerebral angiography to evaluate the severity of CVS( P ＜ 0.01 ).The pathological changes of basilar artery walls were examined.Results Intracisternal infusion of NC - PLGA microspheres and Nicardipine could reduce the severity of CVS.And they could reduce the obvious morphological changes in the artierial wall of BA.Compared with intracisternal infusion of Nicardipine,using 25％ dose of intracisternal infusion of NC - PLGA microspheres could get the same effect.Conclusions The intracisternal infusion of NC - PLGA microspheres could reverse the severity of CVS and reverse the pathologic changement in the arterial wall.The therapeutic course is simple and complication rate is reduced.The technique with polymer should guide the therapy of cerebral vascular disease to some extent.