目的 在区分海马标志点的基础上,测量青年人和老年人正常海马及其头、体、尾3个部位的体积、形态.方法 选择正常青年人(年龄20～29岁,青年组)和老年人(60岁以上,老年组)志愿者各30名进行头部MR扫描,所得图像经后处理软件分析,确定较恒定、易辨认的解剖标志点后对海马进行分割.测量青年组和老年组海马的体积、平均扫描层面积及扫描层数,两组间以及青年组和老年组不同性别、不同侧别海马体积的比较采用独立样本t检验,并作海马的三维重建.结果 60名受试者钩隐窝、脑室三角、钩顶等均能清晰显示.青年组和老年组不同性别间海马体积差异均无统计学意义.青年组左侧海马头部、体部、尾部及整体体积分别为(1250±174)、(653±115)、(372±116)、(2277±109)mm~3,右侧分别为(1255±147)、(657±129)、(386±105)、(2298±213)mm~3,左、右侧间差异均无统计学意义(t值分别为0.08、0.10、0.33、0.35,P值均＞0.05).老年组左侧海马头部、体部、尾部及整体体积分别为(660±109)、(472±92)、(181±73)、(1313±163)mm~3,右侧分别为(717±116)、(474±95)、(240±75)、(1432±171)mm~3,右侧海马尾部体积明显大于左侧,差异具有统计学意义(t=2.21,P＜0.05);其他部位左、右侧海马体积差异均无统计学意义(t值分别为1.39、0.06、1.95,P值均＞0.05).青年组和老年组左侧海马头部、体部、尾部及整体体积差异均有统计学意义(t值分别为15.78、6.71、7.70、20.83,P值均＜0.05),右侧各部位差异也均有统计学意义(t值分别为15.76、6.26、6.15、17.36,P值均＜0.05).老年组各部位体积明显小于青年组,其中以头部最为明显.青年组及老年组海马头部左侧层面积分别为(75±24)、(56±21)mm~2,右侧层面积分别为(73±22)、(58±19)mm2,两组间差异均有统计学意义(t值分别为3.33、2.81,P值均＜0.01).青年组及老年组左侧层数分别为(11.1±3.2)、(7.9±3.9)层,右侧层数分别为(11.5±3.7)、(8.2±3.1)层,两组间差异也均有统计学意义(t值分别为3.48、3.75,P值均＜0.05).老年组的海马头部层数和层面积均小于青年组,呈短而窄的外形.结论 根据海马标志点确认的原则,其所提出的标志点为海马形态体积的标准化测量提供了测量的基础,其所测的正常值有助于疾病的诊断或为某些疾病发病机制的研究提供基础.
目的 在區分海馬標誌點的基礎上,測量青年人和老年人正常海馬及其頭、體、尾3箇部位的體積、形態.方法 選擇正常青年人(年齡20～29歲,青年組)和老年人(60歲以上,老年組)誌願者各30名進行頭部MR掃描,所得圖像經後處理軟件分析,確定較恆定、易辨認的解剖標誌點後對海馬進行分割.測量青年組和老年組海馬的體積、平均掃描層麵積及掃描層數,兩組間以及青年組和老年組不同性彆、不同側彆海馬體積的比較採用獨立樣本t檢驗,併作海馬的三維重建.結果 60名受試者鉤隱窩、腦室三角、鉤頂等均能清晰顯示.青年組和老年組不同性彆間海馬體積差異均無統計學意義.青年組左側海馬頭部、體部、尾部及整體體積分彆為(1250±174)、(653±115)、(372±116)、(2277±109)mm~3,右側分彆為(1255±147)、(657±129)、(386±105)、(2298±213)mm~3,左、右側間差異均無統計學意義(t值分彆為0.08、0.10、0.33、0.35,P值均＞0.05).老年組左側海馬頭部、體部、尾部及整體體積分彆為(660±109)、(472±92)、(181±73)、(1313±163)mm~3,右側分彆為(717±116)、(474±95)、(240±75)、(1432±171)mm~3,右側海馬尾部體積明顯大于左側,差異具有統計學意義(t=2.21,P＜0.05);其他部位左、右側海馬體積差異均無統計學意義(t值分彆為1.39、0.06、1.95,P值均＞0.05).青年組和老年組左側海馬頭部、體部、尾部及整體體積差異均有統計學意義(t值分彆為15.78、6.71、7.70、20.83,P值均＜0.05),右側各部位差異也均有統計學意義(t值分彆為15.76、6.26、6.15、17.36,P值均＜0.05).老年組各部位體積明顯小于青年組,其中以頭部最為明顯.青年組及老年組海馬頭部左側層麵積分彆為(75±24)、(56±21)mm~2,右側層麵積分彆為(73±22)、(58±19)mm2,兩組間差異均有統計學意義(t值分彆為3.33、2.81,P值均＜0.01).青年組及老年組左側層數分彆為(11.1±3.2)、(7.9±3.9)層,右側層數分彆為(11.5±3.7)、(8.2±3.1)層,兩組間差異也均有統計學意義(t值分彆為3.48、3.75,P值均＜0.05).老年組的海馬頭部層數和層麵積均小于青年組,呈短而窄的外形.結論 根據海馬標誌點確認的原則,其所提齣的標誌點為海馬形態體積的標準化測量提供瞭測量的基礎,其所測的正常值有助于疾病的診斷或為某些疾病髮病機製的研究提供基礎.
목적 재구분해마표지점적기출상,측량청년인화노년인정상해마급기두、체、미3개부위적체적、형태.방법 선택정상청년인(년령20～29세,청년조)화노년인(60세이상,노년조)지원자각30명진행두부MR소묘,소득도상경후처리연건분석,학정교항정、역변인적해부표지점후대해마진행분할.측량청년조화노년조해마적체적、평균소묘층면적급소묘층수,량조간이급청년조화노년조불동성별、불동측별해마체적적비교채용독립양본t검험,병작해마적삼유중건.결과 60명수시자구은와、뇌실삼각、구정등균능청석현시.청년조화노년조불동성별간해마체적차이균무통계학의의.청년조좌측해마두부、체부、미부급정체체적분별위(1250±174)、(653±115)、(372±116)、(2277±109)mm~3,우측분별위(1255±147)、(657±129)、(386±105)、(2298±213)mm~3,좌、우측간차이균무통계학의의(t치분별위0.08、0.10、0.33、0.35,P치균＞0.05).노년조좌측해마두부、체부、미부급정체체적분별위(660±109)、(472±92)、(181±73)、(1313±163)mm~3,우측분별위(717±116)、(474±95)、(240±75)、(1432±171)mm~3,우측해마미부체적명현대우좌측,차이구유통계학의의(t=2.21,P＜0.05);기타부위좌、우측해마체적차이균무통계학의의(t치분별위1.39、0.06、1.95,P치균＞0.05).청년조화노년조좌측해마두부、체부、미부급정체체적차이균유통계학의의(t치분별위15.78、6.71、7.70、20.83,P치균＜0.05),우측각부위차이야균유통계학의의(t치분별위15.76、6.26、6.15、17.36,P치균＜0.05).노년조각부위체적명현소우청년조,기중이두부최위명현.청년조급노년조해마두부좌측층면적분별위(75±24)、(56±21)mm~2,우측층면적분별위(73±22)、(58±19)mm2,량조간차이균유통계학의의(t치분별위3.33、2.81,P치균＜0.01).청년조급노년조좌측층수분별위(11.1±3.2)、(7.9±3.9)층,우측층수분별위(11.5±3.7)、(8.2±3.1)층,량조간차이야균유통계학의의(t치분별위3.48、3.75,P치균＜0.05).노년조적해마두부층수화층면적균소우청년조,정단이착적외형.결론 근거해마표지점학인적원칙,기소제출적표지점위해마형태체적적표준화측량제공료측량적기출,기소측적정상치유조우질병적진단혹위모사질병발병궤제적연구제공기출.
Objective In the base of the landmarks of the hippocampus idenffied with neighborhood structures,to measure volumes and shape of normal older age group and youth group's hippocampus and hippocampal head,body,tail.Methods Thirty younger people(age 20-29 years,youth group) and thirty older people (above 60 years,older age group)were scanned by MR ,anatomic landmarks were found ,which were constancy and easy to be recognized for segmentation hippocampus.The hippocampal volumes,average areas and number of the hippocampal layer were measured,the interelass data of two groups,different gender and sides were compared with statistics methods of t test and the hippocampal model were made with the three-dimensional reconstruction. Results All landmarks of 60 subjects could be distinguished clearly,such as uncal recess,triangle of the lateral ventricle,uncal apex et al. The discrepancies of two groups' volumes of gender had not statistical significance.The youth groups' volumes of left hippocampus,head,body and tail were (1250±174) ,(653±115) ,(372±116) ,(2277±109) mm~3,and the right were (1255±147),(657±129),(386±105),(2298±213) mm~3.There was no statistical significance between left and right(t=0.08,0.10,0.33,0.35,P ＞0.05).The older age groups' volumes of left hippocampus,head,body and tail were (660±109),(472±92),(181 ～ 73),(1313±163) mm~3,and the right were (717±116),(474±95),(240±75),(1432±171) mm~3.Older hippocampal volumes were obviously bigger in right tail than in left(t=2.21 ,P＜0.05) ,and other parts had not statistical significance (t=1.39,0.06,1.95,P ＞0.05).There were manifest statistical significance between two groups' left volumes of hippocampus and each parts (t=15.78,6.71,7.70,20.83,P＜ 0.05),and also right (t=15.76,6.26,6.15,17.36,P＜0.05).The hippocampal volumes and its three parts were obviously smaller in older than youth,especially the hippocampal head.The left average areas of youth and older groups' were (75±24),(56±21) mm~2 and the right were (73±22),(58±19) mm~2.Both two groups had manifest statistical significance(t=3.33,2.81,P＜ 0.01).The number of layers of youth and older groups' were (11.1±3.2),(7.9±3.9) layers,and the right were (11.5±3.7),(8.2±3.1) layers.Both two groups had manifest statistical significance (t=3.48,3.75,P＜ 0.05).The number of layers and average areas of hippocampal head were less in older than in youth group,and the shape of hippocampus become short and narrow.Conclusion According to the rule with landmarks that we selected,standardization measurement of the hippocampus may become possible and can be provided the basis of diagnosis and searching pathogenesis related to disease.
