淮海医药
淮海醫藥
회해의약
JOURNAL OF HUAIHAI MEDICINE
2014年
4期
341-343
,共3页
刘洵洵%王佐%范莉莉%徐济宝%吕雪芬
劉洵洵%王佐%範莉莉%徐濟寶%呂雪芬
류순순%왕좌%범리리%서제보%려설분
西地那非%高血压,肺性%新生儿
西地那非%高血壓,肺性%新生兒
서지나비%고혈압,폐성%신생인
Sildenafil%Hypertension,pulmonary%Newborn
目的:观察西地那非治疗新生儿持续肺动脉高压的疗效。方法本资料45例新生儿持续肺动脉高压患儿,其中,观察组25例,为2012年6月-2013年5月入住患者,对照组20例,为2011年6月-2012年5月入住患者;对照组采取常规治疗;观察组在常规治疗的基础上加用西地那非1~1.5 mg/kg,q 6 h,鼻饲,疗程1~2 d。比较2组治疗后肺动脉压( PAH)、吸氧浓度分数( FiO2)、动脉血氧分压( PaO2)变化及不良反应情况,同时比较2组呼吸机使用时间、住院天数。结果治疗后观察组比对照组临床症状及肺动脉压明显改善,且未出现严重不良反应。结论西地那非治疗新生儿持续肺动脉高压,疗效显著,方法简单易行,无不良反应。
目的:觀察西地那非治療新生兒持續肺動脈高壓的療效。方法本資料45例新生兒持續肺動脈高壓患兒,其中,觀察組25例,為2012年6月-2013年5月入住患者,對照組20例,為2011年6月-2012年5月入住患者;對照組採取常規治療;觀察組在常規治療的基礎上加用西地那非1~1.5 mg/kg,q 6 h,鼻飼,療程1~2 d。比較2組治療後肺動脈壓( PAH)、吸氧濃度分數( FiO2)、動脈血氧分壓( PaO2)變化及不良反應情況,同時比較2組呼吸機使用時間、住院天數。結果治療後觀察組比對照組臨床癥狀及肺動脈壓明顯改善,且未齣現嚴重不良反應。結論西地那非治療新生兒持續肺動脈高壓,療效顯著,方法簡單易行,無不良反應。
목적:관찰서지나비치료신생인지속폐동맥고압적료효。방법본자료45례신생인지속폐동맥고압환인,기중,관찰조25례,위2012년6월-2013년5월입주환자,대조조20례,위2011년6월-2012년5월입주환자;대조조채취상규치료;관찰조재상규치료적기출상가용서지나비1~1.5 mg/kg,q 6 h,비사,료정1~2 d。비교2조치료후폐동맥압( PAH)、흡양농도분수( FiO2)、동맥혈양분압( PaO2)변화급불량반응정황,동시비교2조호흡궤사용시간、주원천수。결과치료후관찰조비대조조림상증상급폐동맥압명현개선,차미출현엄중불량반응。결론서지나비치료신생인지속폐동맥고압,료효현저,방법간단역행,무불량반응。
Objective To observe the effect of sildenafil in the treatment of persistent pulmonary hypertension of new born ( PPHN) .Methods 45 cases with PPHN were selected and divided into two groups .The test group included 25 cases of pa-tients admitted between June 1, 2012 and May 31,2013.The control group had 20 cases with patients from June 1,2011 to May 31,2012.The control group was treated with conventional therapy but the test group was aided by sildenafil on the basis of conventional therapy .Comparison between the two groups was conducted in terms of the post -treatment changes of PAH , FiO2 and PaO2 ,adverse reactions as well as the time of using respirator and the time of hospitalization .Results Compared with the control group ,clinical symptoms and PAH had been ameliorated better in the test group .No severe adverse reactions occurred in the two groups .Conclusion Sildenafil in the treatment of PPHN has apparent clinical effect .It can be administered easily with no adverse reaction .It is worth to be promoted in clinical treatment .