CAJ | 학술논문

探讨体外受精-胚胎移植（IVF-ET）周期女性不同阶段焦虑、抑郁情绪变化及其与治疗结局的相关性。方法对117例体外受精-胚胎移植患者应用焦虑自评量表（self-rating anxiety scale,SAS）、抑郁自评量表（self-rating depression scale，SDS）在患者进入周期时（T1期）、取卵前1 d（T2期）、胚胎移植后5～7 d（T3期）进行问卷调查。比较不同时期患者 SAS 和 SDS 评分情况；妊娠与未妊娠组不同时期 SAS 和 SDS 评分情况，用 Logistic 回归分析不同治疗阶段 SAS 评分与是否妊娠的相关性。结果患者 T1、T2、T3期 SDS 评分比较，差异无统计学意义（均 P＞0.05），T1、T2、T3期 SAS 评分比较，差异具有统计学意义（P＜0.05），T2、T3期 SAS 评分明显高于 T1期（均 P＜0.05），T2期 SAS 评分高于 T3期（P＜0.05）。不同治疗阶段两组比较，T2期未妊娠组 SAS 评分明显高于妊娠组（P＜0.05）。Logistic 回归分析显示，T2期 SAS 评分为预测妊娠因素（OR=0.685，P＜0.05），低评分预示高妊娠率。结论行 IVF-ET 治疗的女性患者取卵前期焦虑评分最高；取卵前期未妊娠患者焦虑评分明显高于妊娠者；取卵前期焦虑评分与治疗结局相关，评分较低者临床妊娠率较高。提示在 IVF-ET 周期中需特别关注取卵前期不孕妇女的焦虑情绪。
탐토체외수정-배태이식（IVF-ET）주기녀성불동계단초필、억욱정서변화급기여치료결국적상관성。방법대117례체외수정-배태이식환자응용초필자평량표（self-rating anxiety scale,SAS）、억욱자평량표（self-rating depression scale，SDS）재환자진입주기시（T1기）、취란전1 d（T2기）、배태이식후5～7 d（T3기）진행문권조사。비교불동시기환자 SAS 화 SDS 평분정황；임신여미임신조불동시기 SAS 화 SDS 평분정황，용 Logistic 회귀분석불동치료계단 SAS 평분여시부임신적상관성。결과환자 T1、T2、T3기 SDS 평분비교，차이무통계학의의（균 P＞0.05），T1、T2、T3기 SAS 평분비교，차이구유통계학의의（P＜0.05），T2、T3기 SAS 평분명현고우 T1기（균 P＜0.05），T2기 SAS 평분고우 T3기（P＜0.05）。불동치료계단량조비교，T2기미임신조 SAS 평분명현고우임신조（P＜0.05）。Logistic 회귀분석현시，T2기 SAS 평분위예측임신인소（OR=0.685，P＜0.05），저평분예시고임신솔。결론행 IVF-ET 치료적녀성환자취란전기초필평분최고；취란전기미임신환자초필평분명현고우임신자；취란전기초필평분여치료결국상관，평분교저자림상임신솔교고。제시재 IVF-ET 주기중수특별관주취란전기불잉부녀적초필정서。
Objective To study the correlations of anxiety and depression at different phases with curative outcomes in female patients at IVF-ET cycle.Methods One hundred and seventeen patients were involved the study using the Self-Rating Anxiety Scale (SAS), Self-Rating Depression(SDS)questionnaires when registered for IVF-ET cycle(T1), one day prior to oocyte retrieval(T2), and 5 to 7 days after embryo transfer(T3).SDS scores and SAS scores were compared between different phases.Logistic regression was used to analyze the correlation of SAS scores with outcome.Results SDS scores of T1, T2 and T3 phases showed no significant differences(all P<0.05).The SAS scores at T2 and T3 were higher than that at T1(all P<0.05), the SAS scores at T2 were higher than that at T3(P<0.05).The SAS scores at T2 in patients achieved clinical pregnancy were significantly lower than that in patients achieved no clinical pregnancy.Logistic regression model showed that lower SAS scores were associated with higher pregnancy rates (P<0.05).Conclusions Anxiety level is the most remarkable one in the phase prior to oocyte retrieval.Low anxiety level prior to oocyte retrieval predicts higher a pregnancy rate.