CAJ | 학술논문

目的：探讨米非司酮联合米索前列醇配合清宫术终止8~12周妊娠的临床疗效.方法选择2012年5月~2013年5月在河北省邢台市任县医院妇产科门诊接受终止妊娠手术240例患者,其均为宫内妊娠并停经8~12周,将患者随机分为观察者与对照组,每组各120例.观察组采用米非司酮联合米索前列醇配合清宫术终止妊娠,对照组采用人工流产手术,术前使用0.2%利多卡因局部浸润麻醉.观察两组患者手术成功率、手术时间、术中出血量、宫口扩张情况、患者痛苦程度及术后恶心、呕吐、发热、腹痛、出血、手麻等不良反应.结果观察组手术成功率为98.3%,与对照组患者人流手术成功率(99.2%)比较,差异无统计学意义(P>0.05),但观察组宫口扩张总有效率为98.3%,明显高于对照组(77.5%),差异有统计学意义(字2=12.31,P<0.05).观察组手术时间、术中出血量及疼痛程度分别为(4.80±0.86)min、(10.70±2.57)mL、(1.90±0.51),均明显低于对照组的(7.30±1.23)min、(16.60±4.32)mL、(2.38±0.67),差异有统计学意义(P<0.05).两组患者均出现不同程度不良反应,但两组发生情况差异无统计学意义(P>0.05).结论米非司酮联合米索前列醇配合清宫术终止8~12周妊娠可促进宫颈松驰,软化宫颈,创伤小,并能够缓解术中痛苦,减少术中出血量,是一种安全、有效、实用的流产方法,值得推广。
목적：탐토미비사동연합미색전렬순배합청궁술종지8~12주임신적림상료효.방법선택2012년5월~2013년5월재하북성형태시임현의원부산과문진접수종지임신수술240례환자,기균위궁내임신병정경8~12주,장환자수궤분위관찰자여대조조,매조각120례.관찰조채용미비사동연합미색전렬순배합청궁술종지임신,대조조채용인공유산수술,술전사용0.2%리다잡인국부침윤마취.관찰량조환자수술성공솔、수술시간、술중출혈량、궁구확장정황、환자통고정도급술후악심、구토、발열、복통、출혈、수마등불량반응.결과관찰조수술성공솔위98.3%,여대조조환자인류수술성공솔(99.2%)비교,차이무통계학의의(P>0.05),단관찰조궁구확장총유효솔위98.3%,명현고우대조조(77.5%),차이유통계학의의(자2=12.31,P<0.05).관찰조수술시간、술중출혈량급동통정도분별위(4.80±0.86)min、(10.70±2.57)mL、(1.90±0.51),균명현저우대조조적(7.30±1.23)min、(16.60±4.32)mL、(2.38±0.67),차이유통계학의의(P<0.05).량조환자균출현불동정도불량반응,단량조발생정황차이무통계학의의(P>0.05).결론미비사동연합미색전렬순배합청궁술종지8~12주임신가촉진궁경송치,연화궁경,창상소,병능구완해술중통고,감소술중출혈량,시일충안전、유효、실용적유산방법,치득추엄。
Objective To study the clinical effect of Mifepristone combined Misoprostol together with complete curet-tage of uterine cavity in terminating pregnancy of 8 to 12 weeks. Methods 240 patients receiving termination of preg-nancy operation in the Department of Obstetrics and Gynecology out-patient of Ren County Hospital of Xingtai City from May 2012 to May 2013, who were intrauterine pregnancy and gestation with 8-12 weeks, were randomly divided into the observation group and the control group, 120 cases in each group. The observation group was given the treat-ment of Mifepristone combined Misoprostol together with complete curettage of uterine cavity, and the patients of con-trol group were was given the treatment of abortion with 0.2%Lidocaine local infiltration preoperative anesthesia. Oper-ation success rate, operation time, intraoperative bleeding volume, cervical dilatation, pain and postoperative side ef-fects, such as nausea, vomiting, fever, abdominal pain, diarrhea, bleeding, numbness in the hand were observed. Re-sults The difference between the observation group operation success rate (98.3%) and the control group patients in-duced abortion operation success rate (99.2%) was not significant (P>0.05), but the dilatation of cervix total efficiency in the observation group (98.3%) was significantly higher than that in the control group (77.5%), the difference was sta-tistically significant (χ2=12.31, P< 0.05). The operation time, the amount of bleeding and severe pain of observation group were (4.80±0.86) min, (10.70±2.57) mL and (1.90±0.51), which were significantly less than that of the control group [(7.30±1.23) min, (16.60±4.32) mL, (2.38±0.67)], there were significant differences between the two groups (P< 0.05). The patients of two groups had adverse reactions with different degree, but the two groups had no significant difference (P>0.05). Conclusion Mifepristone combined Misoprostol together with complete curettage of uterine cavity in termi-nating pregnancy of 8-12 weeks can promote cervical relaxation, make cervical softening, reduce trauma, and can re-lieve the distress of patients, reduce the amount of bleeding. It is a safe, effective, practical method of abortion, worthy of promotion.