CAJ | 학술논문

目的：探索解脲支原体感染(UU)与早产儿支气管肺发育不良(BPD)的关系,以期为降低早产儿感染的发生率提供±据.方法收集浙江省诸暨市妇幼保健院2011年2月~2012年9月胎龄(<35周)的152例早产儿脐带血,采用荧光定量PCR技术和放射免疫技术测定UU、血培养、白细胞(WBC)、C反应蛋白白(CRP)和白介素(IL)-8.根据UU检测结果分为UU阳性组和UU阴性组,对两组的基本资料、临床产科资料和实验室检查数据采用t检验和字2检验进行统计学处理,分析UU和早产儿BPD的关系及其相关因素.结果152例早产儿UU阳性者26例(17.11%),UU阴性者126例(82.89%). UU阳性组BPD 6例(23.08%),UU阴性组BPD 6例(4.76%),UU阳性组 BPD发病率明显高于阴性组(字2=9.942,P <0.01)；26例 UU 阳性者出生平均体重为(1022.43±466.68)g,126例UU阴性者平均出生体重为(1678.75±667.27)g,UU阳性组体重明显低于阴性组(t=4.7741,P<0.01)；UU阳性组的阴道分娩、胎儿早破和绒毛膜羊膜炎构成比均明显高于UU阴性组(字2=6.545、7.611、5.302,P<0.05或P<0.01)；UU阳性组CRP和IL-8均明显低于UU阴性组(t=1.264,P=0.000；字2=12.819,P=0.000). Logistic回归分析显示相对于UU阴性,BPD相关因素为阴道分娩、胎膜早破、绒毛膜羊膜炎和IL-8(OR=1.149、3.300、2.875、4.183,均P<0.05).结论 UU感染是早产儿BPD产生的一个重要原因,针对UU感染及相关因素采用恰当干预措施,可减少患儿感染。
목적：탐색해뇨지원체감염(UU)여조산인지기관폐발육불량(BPD)적관계,이기위강저조산인감염적발생솔제공±거.방법수집절강성제기시부유보건원2011년2월~2012년9월태령(<35주)적152례조산인제대혈,채용형광정량PCR기술화방사면역기술측정UU、혈배양、백세포(WBC)、C반응단백백(CRP)화백개소(IL)-8.근거UU검측결과분위UU양성조화UU음성조,대량조적기본자료、림상산과자료화실험실검사수거채용t검험화자2검험진행통계학처리,분석UU화조산인BPD적관계급기상관인소.결과152례조산인UU양성자26례(17.11%),UU음성자126례(82.89%). UU양성조BPD 6례(23.08%),UU음성조BPD 6례(4.76%),UU양성조 BPD발병솔명현고우음성조(자2=9.942,P <0.01)；26례 UU 양성자출생평균체중위(1022.43±466.68)g,126례UU음성자평균출생체중위(1678.75±667.27)g,UU양성조체중명현저우음성조(t=4.7741,P<0.01)；UU양성조적음도분면、태인조파화융모막양막염구성비균명현고우UU음성조(자2=6.545、7.611、5.302,P<0.05혹P<0.01)；UU양성조CRP화IL-8균명현저우UU음성조(t=1.264,P=0.000；자2=12.819,P=0.000). Logistic회귀분석현시상대우UU음성,BPD상관인소위음도분면、태막조파、융모막양막염화IL-8(OR=1.149、3.300、2.875、4.183,균P<0.05).결론 UU감염시조산인BPD산생적일개중요원인,침대UU감염급상관인소채용흡당간예조시,가감소환인감염。
Objective To explore the relation between ureaplasma urealyticum infection (UU) and preterm children bronchopulmonary dysplasia (BPD) and provide evidence for reducing the incidence of infection in preterm children. Methods One hundred and fifty-two infants and gestational age (< 35 weeks) of premature in Maternal and Child Health Hospital of Zhuji from February 2011 to September 2012 were collected, UU, blood culture, WBC, CRP and IL-8 of umbilical cord blood were detected by fluorogenic quantitative PCR technique and radioimmunoassay. These in-fants were divided into UU positive group and negative group according to the test results, t-test and χ2 test were used for the basic, clinical obstetric and laboratory data of the two groups, then relationship and its related factors of UU and BPD in preterm children were analyzed. Results UU positive infants were 26 cases in 152 cases of premature (17.11%), UU negative were 126 cases (82.89%). There were 6 cases of BPD in UU positive group (23.08%), UU nega-tive group were also 6 cases (4.76%), the difference was statistically significant (χ2=9.942, P<0.01). Average weight of 26 UU positive was (1022.43±466.68) g, 126 cases of UU negative was (1678.75±667.27) g, the difference was statisti-cally significant (t=4.7741, P<0.01). The difference of vagina birth, premature rupture of the fetal and chorioamnioni-tis in UU positive group and negative group were statistically significant (χ2=6.545, 7.611, 5.302, P< 0.05), and the differences of CRP and IL-8 in UU positive group and negative group were statistically significance (t=1.264, P=0.000;χ2=12.819, P=0.000). Logistic regression analysis showed that relative to the UU negative, BPD-related factors were vaginal delivery, premature rupture of membranes, chorioamnionitis and IL-8 (OR= 1.149, 3.300, 2.875, 4.183; P <0.05). Conclusion UU infection is one important reason that can cause BPD in preterm children, using appropriate in-terventions for UU infection and related factors can reduce infection in children.