CAJ | 학술논문

目的：了解2012年1月-2013年12月本院念珠菌感染状况和药敏情况。方法临床标本经接种培养，开放性部位标本若培养出以念珠菌为优势菌株和无菌部位标本培养出念珠菌均进一步进行纯培养及药敏试验。结果880例念珠菌以白色念珠菌为主要致病菌，其次为光滑念珠菌、热带念珠菌、近平滑念珠菌；主要来源于老年人群，不同年龄人群念珠菌分布具有明显差异(P<0.01)；男性多于女性；以痰标本最多，尿液其次，胃液最少，不同标本来源分布具有明显差异(P<0.01)；念珠菌感染主要来自于心脑血管、肺部疾病患者，不同临床诊断类型的念珠菌感染具有明显差异(P<0.01)；不同念珠菌对氟康唑、伏立康唑的敏感性具有统计学差异(P<0.05)，以光滑念珠菌、热带念珠菌对氟康唑、伏立康唑耐药率最高。结论白色念珠菌为本院念珠菌感染最为常见菌株，光滑念珠菌次之，在治疗心脑血管患者、老年患者，要警惕发生念珠菌等二重感染，一旦发生，要根据念珠菌药敏试验合理用药。
목적：료해2012년1월-2013년12월본원념주균감염상황화약민정황。방법림상표본경접충배양，개방성부위표본약배양출이념주균위우세균주화무균부위표본배양출념주균균진일보진행순배양급약민시험。결과880례념주균이백색념주균위주요치병균，기차위광활념주균、열대념주균、근평활념주균；주요래원우노년인군，불동년령인군념주균분포구유명현차이(P<0.01)；남성다우녀성；이담표본최다，뇨액기차，위액최소，불동표본래원분포구유명현차이(P<0.01)；념주균감염주요래자우심뇌혈관、폐부질병환자，불동림상진단류형적념주균감염구유명현차이(P<0.01)；불동념주균대불강서、복립강서적민감성구유통계학차이(P<0.05)，이광활념주균、열대념주균대불강서、복립강서내약솔최고。결론백색념주균위본원념주균감염최위상견균주，광활념주균차지，재치료심뇌혈관환자、노년환자，요경척발생념주균등이중감염，일단발생，요근거념주균약민시험합리용약。
Objective To understand the infection status and drug susceptibility of candida in our hospital from Jan.2012 to Dec. 2013. Methods Clinical specimens were inoculated culture. When candida strains were advantage strains in the specimens from open position or candida strains were come from the sterile specimens, these were further cultivated and tested for drug suscepti-bility. Results A total of 888 candida strains were detected,most of which were candida albicans,followed by smooth candida, tropical candida, nearly smooth candida; Mainly from the older population, candida distribution had obvious difference in different age groups (P<0.01);Men more than women;With sputum specimens were most, urine second, gastric juice to a minimum, it had obvious difference in specimen source distribution (P<0.01); Candida infection were mainly from patients with lung disease and heart head blood-vessel disease, it had obvious difference in different clinical diagnosed patients (P<0.01);The sensitivity to flu-conazole and voriconazole had statistically difference in different candida(P<0.05), smooth candida and tropical candida were high-er than other candida. Conclusion Candida albicans is the main pathogen of fungal infection, next, smooth candida. Elderly pa-tients and cardiovascular patients should guard candida infections in double. Clinical antifungal therapy should be based on the results of strain identification and antifungal susceptibility testing.