CAJ | 학술논문

目的：探讨新生儿重度血小板减少症的病因及临床特点。方法回顾性分析30例重度血小板减少症的新生儿的临床治疗情况。结果30例血小板减少症患儿中足月儿15例，早产儿15例；平均胎龄（35.0±4.8）周；平均体重（2.19±0.94） kg；宫内生长迟缓、宫内感染、晚发败血症、坏死性小肠结肠炎等为常见病因。其中早发性重度血小板减少症最常见病因为宫内生长迟缓，而晚发性重度血小板减少症最常见病因为晚发败血症或坏死性小肠结肠炎。重度血小板减少患儿发生出血13例（43.33%），但按血小板计数进行分组比较临床出血情况，其差异无统计学意义（P>0.05）。结论新生儿重度血小板减少症常见病因为宫内生长迟缓、宫内感染、晚发败血症、坏死性小肠结肠炎，出血比例高，需早期明确诊断，及时给予针对性治疗。
목적：탐토신생인중도혈소판감소증적병인급림상특점。방법회고성분석30례중도혈소판감소증적신생인적림상치료정황。결과30례혈소판감소증환인중족월인15례，조산인15례；평균태령（35.0±4.8）주；평균체중（2.19±0.94） kg；궁내생장지완、궁내감염、만발패혈증、배사성소장결장염등위상견병인。기중조발성중도혈소판감소증최상견병인위궁내생장지완，이만발성중도혈소판감소증최상견병인위만발패혈증혹배사성소장결장염。중도혈소판감소환인발생출혈13례（43.33%），단안혈소판계수진행분조비교림상출혈정황，기차이무통계학의의（P>0.05）。결론신생인중도혈소판감소증상견병인위궁내생장지완、궁내감염、만발패혈증、배사성소장결장염，출혈비례고，수조기명학진단，급시급여침대성치료。
Objective To investigate the cause and clinical characteristics of severe neonatal thrombocytopenia (NT). Methods A retrospective analysis was performed to analyze causes and prognosis for severe NT among a group of 30 cases with severe NT.Result Among the 30 cases with severe NT, 15 were term infants and 15 were preterm infants. The median gestational age of 30 enrolled neonates was 35.0±4.8weeks and the median birth weight was 2.19±0.94 kg. Common causes for severe NT included:intrauterine growth restriction (IUGR), intrauterine infection, late-onset of sepsis or necrotizing enterocolitis (NEC), etc. IUGR was the most frequent cause for early-onset severe thrombocytopenia. Late-onset of sepsis or NEC was the most frequent cause for late-onset severe thrombocytopenia. The cases of bleeding were 13 (43.33%), but there was no statistically significant correlation between platelet counts and bleeding (P>0.05).Conclusion Common causes for severe NT include: IUGR, intrauterine infection, late-onset of sepsis or NEC, etc. The risk of bleeding for severe NT is high. Earlier diagnosis of the cause for severe NT and tailed treatments can achieve better efficacy.