CAJ | 학술논문

许多研究表明,人乳头瘤病相关肿瘤中存在DNA甲基化、组蛋白修饰等各种表观遗传学改变.在这些表观遗传学改变的研究中,提示E6和E7可能对人乳头瘤病毒相关肿瘤的DNA甲基化及组蛋白修饰存在直接或间接的影响.其中一个重要的机制可能是E6和E7直接与上述表观遗传学路径中涉及的相关蛋白酶相互作用.进一步明确E6、E7通过DNA甲基化和组蛋白修饰路径的致癌机制.
허다연구표명,인유두류병상관종류중존재DNA갑기화、조단백수식등각충표관유전학개변.재저사표관유전학개변적연구중,제시E6화E7가능대인유두류병독상관종류적DNA갑기화급조단백수식존재직접혹간접적영향.기중일개중요적궤제가능시E6화E7직접여상술표관유전학로경중섭급적상관단백매상호작용.진일보명학E6、E7통과DNA갑기화화조단백수식로경적치암궤제.
There have been evidences that epigenetic changes such as DNA methylation and histone modification exist in human papilloma virus 16 (HPV16)-associated tumors.Some epigenetic researches have shown that the E6/E7 protein of HPV16 might have a direct or indirect impact on DNA methylation and histone modification in HPV-associated tumors.Additionally,one of the most important mechanisms might be that the E6/E7 protein directly interacts with enzymes involved in the epigenetic pathways.A better understanding of mechanisms underlying HPV 16-induced tumorigenesis via DNA methylation and histone modification may offer theoretical basis for the development of treatments for HPV-associated tumors.