CAJ | 학술논문

胰岛素（insulin）及其信号传导途径在细胞中发挥调节糖、脂肪和蛋白质代谢，影响生物的生长、代谢、生殖、衰老等功能[1]。自首个昆虫类胰岛素-家蚕素（Bombyxin）在家蚕体内被发现以来，其结构、分布、调控基因、分泌控制及其在生理学上的功能已部分被阐明。家蚕素一级结构与人胰岛素大约有40％的同源性，主要在家蚕脑组织中表达，其代谢调控作用等相关研究已取得较大进展。本文将在相关文献基础上对家蚕素信号通路及其在调控家蚕代谢、生长及发育的研究进展上做一综述。
이도소（insulin）급기신호전도도경재세포중발휘조절당、지방화단백질대사，영향생물적생장、대사、생식、쇠로등공능[1]。자수개곤충류이도소-가잠소（Bombyxin）재가잠체내피발현이래，기결구、분포、조공기인、분비공제급기재생이학상적공능이부분피천명。가잠소일급결구여인이도소대약유40％적동원성，주요재가잠뇌조직중표체，기대사조공작용등상관연구이취득교대진전。본문장재상관문헌기출상대가잠소신호통로급기재조공가잠대사、생장급발육적연구진전상주일종술。
Insulin and its signal transduction pathways play very important roles in the regulation of the grow th ,metabolism ,reproduction and aging of organisms .Bombyxin ,the first insulin-like substance from an insect ,was discovered in silkworm (Bombyx mori) .Since then ,its structure ,distribution ,regulating genes ,secretion control and physiological functions have been studied .The primary structure of bombyxin shares about 40% identity with that of hu-man insulin and its genes are expressed predominantly in the brain .At present ,considerable progress has been made of its metabolic regulation and control functions .Based on the literature a-vailable ,this paper makes a review of the recent advances in the research of the signaling pathways of bombyxin and its regulation of the metabolism ,growth and development in silkworm .