CAJ | 학술논문

目的：探讨肝动脉介入(TACE)联合甘露聚糖肽治疗原发性肝癌的临床疗效。方法：回顾性分析我院进行TACE加甘露聚糖肽治疗的原发性肝癌患者80例，随机分为观察组和对照组，各40例，均选择股动脉插管，造影显影后，灌注5-氟尿嘧啶，阿霉素，顺铂，碘油栓塞，每周1次，连续2次。观察组在此治疗基础上静脉点滴甘露聚糖肽注射液，1次/天。结果：观察组实体瘤临床有效率与对照组比较差异无统计学意义(P=0.24)。观察组患者KPS评分和血CD4+、CD4+/CD8+、NK细胞水平均较对照组显著增高(P<0.05)。结论：应用甘露聚糖肽联合TACE治疗原发性肝癌能有效增强患者机体免疫功能，提高瘤临床有效率，改善生活质量。
목적：탐토간동맥개입(TACE)연합감로취당태치료원발성간암적림상료효。방법：회고성분석아원진행TACE가감로취당태치료적원발성간암환자80례，수궤분위관찰조화대조조，각40례，균선택고동맥삽관，조영현영후，관주5-불뇨밀정，아매소，순박，전유전새，매주1차，련속2차。관찰조재차치료기출상정맥점적감로취당태주사액，1차/천。결과：관찰조실체류림상유효솔여대조조비교차이무통계학의의(P=0.24)。관찰조환자KPS평분화혈CD4+、CD4+/CD8+、NK세포수평균교대조조현저증고(P<0.05)。결론：응용감로취당태연합TACE치료원발성간암능유효증강환자궤체면역공능，제고류림상유효솔，개선생활질량。
Objective: To investigate the clinical efficacy of Mannatide combined with hepatic artery interventional therapy in the treatment of primary liver cancer. Methods: Retrospective analysis of TACE plus Mannatide injection in the treatment of 80 cases of primary liver cancer patients in our hospital, were randomly divided into observation group and control group, each 40 cases, were selected for femoral artery, angiography after development, perfusion 5-lfuorouracil, doxorubicin, cisplatin, lipiodol embolization, 1 times a week, continuous 2 times. The observation group was treated with intravenous drip Mannatide Injection, 1 times/day. Results: There was no significant difference of solid tumor clinical efficiency observation group compared with the control group (P=0.24). Patients in the observation group the KPS score and serum CD4+, CD4+/CD8+, NK cells was signiifcantly higher than control group(P<0.05). Conclusion:The application of mannan peptide combined with TACE in the treatment of primary liver cancer can effectively enhance the immune function of patients with tumor, improve clinical efifciency, improve the quality of life.