CAJ | 학술논문

目的：探讨阿托伐他汀钙片治疗冠心病(CHD)合并高脂血症的临床疗效。方法：选取2011年6月至2012年12月于我院门诊治疗的CHD合并高脂血症患者79例，男性45例，女性34例，年龄42～77岁，平均（56.9±4.1）岁。在基础治疗与常规护理的基础上，随机分为两组，观察组40例，男性23例，女性17例，年龄42～77岁，平均（56.7±5.1）岁，给予阿托伐他汀钙片（口服，20mg/次，1日1次，1疗程10d，连续服用4疗程）实施治疗。对照组39例，男性22例，女性17例，年龄43～76岁，平均（57.1±3.2）岁，给予血脂康（口服，2片/次，1日3次，1疗程10d，连续服用4疗程）实施治疗。对治疗前后两组患者的血脂水平进行对比与分析，观察指标包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇（HDL-C）及两组临床疗效。结果：（1）治疗4个疗程后,两组的血脂(TC、TG、LDL-C及HDL-C)水平均出现显著变化,两组治疗后比治疗前有后相比有明显差异,P＜0.05；观察组变化水平明显优于对照组，P＜0.05。（2）两组临床疗效：总有效率观察组明显高于对照组（P＜0.05）。结论：阿托伐他汀钙片治疗CHD合并高脂血症，可有效改善血脂水平，提高有效率，疗效确切。
목적：탐토아탁벌타정개편치료관심병(CHD)합병고지혈증적림상료효。방법：선취2011년6월지2012년12월우아원문진치료적CHD합병고지혈증환자79례，남성45례，녀성34례，년령42～77세，평균（56.9±4.1）세。재기출치료여상규호리적기출상，수궤분위량조，관찰조40례，남성23례，녀성17례，년령42～77세，평균（56.7±5.1）세，급여아탁벌타정개편（구복，20mg/차，1일1차，1료정10d，련속복용4료정）실시치료。대조조39례，남성22례，녀성17례，년령43～76세，평균（57.1±3.2）세，급여혈지강（구복，2편/차，1일3차，1료정10d，련속복용4료정）실시치료。대치료전후량조환자적혈지수평진행대비여분석，관찰지표포괄총담고순（TC）、감유삼지（TG）、저밀도지단백담고순(LDL-C)급고밀도지단백담고순（HDL-C）급량조림상료효。결과：（1）치료4개료정후,량조적혈지(TC、TG、LDL-C급HDL-C)수평균출현현저변화,량조치료후비치료전유후상비유명현차이,P＜0.05；관찰조변화수평명현우우대조조，P＜0.05。（2）량조림상료효：총유효솔관찰조명현고우대조조（P＜0.05）。결론：아탁벌타정개편치료CHD합병고지혈증，가유효개선혈지수평，제고유효솔，료효학절。
Objective:To discusse atorvastatin calcium clinical efifcacy of coronary heart disease(CHD) and hyperlipidemia.Methods:Select from June 2011 to December 2012 in our hospital merger in the treatment of CHD in patients with hyperlipidemia in 79 cases, male 45 cases, female 34 cases, aged 42 to 77 years, mean (56.9±4.1) years of age. On the basis of treatment and routine care on the basis of randomly divided into two groups, the observation group, 40 patients, 23 males and 17 females, aged 42 to 77 years, mean (56.7±5.1) years of age, to give atorvastatin calcium (oral, 20mg/times, 1 time a day, 1 course 10d, for taking four courses) implementation of treatment. 39 cases in the control group, 22 males and 17 females, aged 43 to 76 years, mean (57.1±3.2) years old, give Xuezhikang (oral, 2/times, three times a day, a course of 10d, taking four consecutive course) to implement treatment. Lipid levels before and after treatment were compared two groups of patients and analysis, outcome measures, including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol(HDL-C) and clinical efifcacy.Results:(1) After treatment four courses, two sets of blood lipids (TC, TG, LDL-C and HDL-C) mean signiifcant change in water, after treatment than before treatment were signiifcantly different compared to after, P<0.05;levels in the observation group than the control group, P<0.05. (2) the clinical efifcacy of the two groups:the total efifciency of the observation group was signiifcantly higher(P<0.05).Conclusions:Atorvastatin calcium treatment of hyperlipidemia in CHD, which can effectively improve blood lipid levels, improve efifciency, and effective.