CAJ | 학술논문

目的：研究高血压合并非酒精性脂肪性肝病（NAFLD）与胰岛素抵抗(IR)、同型半胱氨酸(Hcy)的关系及相关影响因素。方法：原发性高血压患者200例分为2组：(1)高血压合并NAFLD组（A组）102例。(2)单纯高血压组（B组）98例。测量身高、体重、血压、血脂、肝酶、血糖、Hcy等指标，计算体重指数（BMI）、IR指数（HOMA指数），两组进行比较。结果：A组BMI、收缩压（SBP）、甘油三酯（TG）、空腹胰岛素（FINS）、空腹血糖（FBG）、HOMA指数、Hcy较B组明显升高（P<0.05），logistic回归分析显示BMI、FINS、TG、FBG、Hcy是A组主要危险因素。结论：IR、血脂代谢紊乱、高Hcy血症增加高血压合并NAFLD的患病风险。
목적：연구고혈압합병비주정성지방성간병（NAFLD）여이도소저항(IR)、동형반광안산(Hcy)적관계급상관영향인소。방법：원발성고혈압환자200례분위2조：(1)고혈압합병NAFLD조（A조）102례。(2)단순고혈압조（B조）98례。측량신고、체중、혈압、혈지、간매、혈당、Hcy등지표，계산체중지수（BMI）、IR지수（HOMA지수），량조진행비교。결과：A조BMI、수축압（SBP）、감유삼지（TG）、공복이도소（FINS）、공복혈당（FBG）、HOMA지수、Hcy교B조명현승고（P<0.05），logistic회귀분석현시BMI、FINS、TG、FBG、Hcy시A조주요위험인소。결론：IR、혈지대사문란、고Hcy혈증증가고혈압합병NAFLD적환병풍험。
Objective: To investigate the association of nonalcoholic fatty liver disease(NAFLD)with insulin resistance(IR) and homocysteine(Hcy) in patients with essential hypertension, and to analyze the risk factors.Methods:A total of 200 patients with hypertension including 102 with NAFLD and 98 without NAFLD were recruited.Height,weight,blood pressure, blood lipids,liver enzymes,fasting blood glucose(FBG), Hcy and HbA1c levels were detected.Body mass index(BMI), IR index(HOMA index) were calculated and compared between two groups.Results:Compared with non-NAFLD group, BMI, triglyceride(TG), HOMA index were signiifcantly higher in NAFLD group(P<0.05), Logistic regression analysis showed that BMI,TG,FINS,FBG,IR index,Hcy were independent factors.Conclusion:IR, lipid disorders and Hcy were signiifcantly associated with increased risk of NAFLD in in patients with essential hypertension.