CAJ | 학술논문

目的：探讨利伐沙班对成人膝部骨肿瘤术后静脉血栓栓塞的预防效果。方法选取成人膝部骨肿瘤术后100例，随机分为利伐沙班和低分子量肝素2组，每组50例，观察各组静脉血栓发生率、D-二聚体数值变化、手术前后血小板计数（PLT）及活化部分凝血活酶时间（APTT）变化，全膝关节置换后形成血肿情况，发生THA消化道出血几率。结果100例患者中均未发现有下肢静脉血栓的形成，2例有右膝关节全膝关节置换后形成血肿，3例患者发生THA消化道出血。利伐沙班组中发现1例静脉血栓患者，为不完全血栓，无临床症状。而低分子量肝素组发现3例静脉血栓患者，肿胀、疼痛症状出现，而后消失。术后1d、3d、7d和14d利伐沙班组D-二聚体明显低于低分子量肝素组。结论合理的使用利伐沙班，对成人膝部骨肿瘤术后静脉血栓栓塞的预防具有显著的疗效。
목적：탐토리벌사반대성인슬부골종류술후정맥혈전전새적예방효과。방법선취성인슬부골종류술후100례，수궤분위리벌사반화저분자량간소2조，매조50례，관찰각조정맥혈전발생솔、D-이취체수치변화、수술전후혈소판계수（PLT）급활화부분응혈활매시간（APTT）변화，전슬관절치환후형성혈종정황，발생THA소화도출혈궤솔。결과100례환자중균미발현유하지정맥혈전적형성，2례유우슬관절전슬관절치환후형성혈종，3례환자발생THA소화도출혈。리벌사반조중발현1례정맥혈전환자，위불완전혈전，무림상증상。이저분자량간소조발현3례정맥혈전환자，종창、동통증상출현，이후소실。술후1d、3d、7d화14d리벌사반조D-이취체명현저우저분자량간소조。결론합리적사용리벌사반，대성인슬부골종류술후정맥혈전전새적예방구유현저적료효。
Objective To investigate the effect of rivaroxaban for venous thromboembolism in adults with knee bone tumors.Methods 100 adults with knee bone tumors were randomly divided into rivaroxaban and low molecular weight heparin group,50 cases in each group , incidence of venous thrombosis , D-dimer values change , platelet count before and after surgery ( PLT) and activated partial thromboplastin time ( APTT ) changes after total knee joint replacement hematoma formation , the probability of occurrence of gastrointestinal bleeding THA were observed .Results There had no formed deep vein thrombosis in the 100 patients,2 patients had right knee hematoma formation after total knee replacement ,and 3 THA patients with gastrointesti-nal bleeding.50 patients in rivaroxaban group had 1 case of venous thrombosis,2% of incomplete thrombosis,without clinical symptoms.Low molecular weight heparin group found 3 cases of venous thrombosis ,6%,swelling,pain and symptoms appeared , then disappeared .Postoperative rivaroxaban 1 d,3 d,7 d and 14 d D-dimer was significantly lower than that of the low molecular weight heparin group .Conclusion Rational use of rivaroxaban has a significant effect for preventing venous thromboembolism in adults with knee bone tumors .