CAJ | 학술논문

目的：观察热化疗治疗老年口腔颌面部恶性肿瘤的疗效。方法选择2009年9月至2012年11月60例老年口腔颌面恶性肿瘤患者为研究对象，随机分成2组。热化疗组在全身化疗的同时给予局部的超声热化疗，温度40～42℃，每次时间40 min，隔日1次，总计5次，28天为1个周期，进行2～3个周期。常规化疗组，仅接受2～3个周期的相同方案化疗。对2组治疗有效率进行评价。结果超声热化疗组的有效率为51．61％（16/31），常规化疗组有效率为20．69％（6/29），差异具有统计学意义（P＜0．05）。结论热化疗可以显著提高化疗有效率，该方法安全、可行，且未见有相关严重的不良反应，适合在临床推广应用。
목적：관찰열화료치료노년구강합면부악성종류적료효。방법선택2009년9월지2012년11월60례노년구강합면악성종류환자위연구대상，수궤분성2조。열화료조재전신화료적동시급여국부적초성열화료，온도40～42℃，매차시간40 min，격일1차，총계5차，28천위1개주기，진행2～3개주기。상규화료조，부접수2～3개주기적상동방안화료。대2조치료유효솔진행평개。결과초성열화료조적유효솔위51．61％（16/31），상규화료조유효솔위20．69％（6/29），차이구유통계학의의（P＜0．05）。결론열화료가이현저제고화료유효솔，해방법안전、가행，차미견유상관엄중적불량반응，괄합재림상추엄응용。
Objective To observe the efficacy of theramo-chemotherapy for elderly patients with oral and maxillofacial malignant tumor .Methods 60 cases of elderly patients with oral and maxillofacial malignant tumor were randomly divided into 2 groups.Thermo-chemotherapy group (n=31) at the same time received local chemotherapy ultrasonic heat ,temperature 40 ~42℃,each time 40 min,every other day,for 5 times,and 28 days for a period,for 2 to 3 cycles.Conventional chemotherapy group (n=29),the same regimen received only 2 to 3 cycles.Effective treatment for the 2 groups were evaluated .Results Effective rates of the ultrasonic thermo-chemotherapy group and the conventional chemotherapy group were 51.61%(16/31) and 20.69%(6/29),the difference was statistically significant (P<0.05).Conclusion Chemotherapy can significantly improve the thermal ef-ficiency of chemotherapy ,it is safe,feasible,without serious adverse reactions ,and it is suitable for clinical application .