CAJ | 학술논문

目的：探讨微创手术对肺癌患者免疫功能的影响。方法将168例非小细胞肺癌患者，根据治疗方式不同分为微创组和传统组，比较2组患者的术前、术后12h和72h的细胞炎性因子水平和术前、术后2d和7d 免疫细胞含量。结果与术前相比，术后2组患者各项细胞炎性因子的含量均明显提高，且差异具有统计学意义（ P＜0．05）。术后IL-6，IL-2R，CRP的含量组间的差异无统计学意义（P＞0．05）。 SAA水平术后12 h后组间差异有统计学意义（P＜0．05）。2组患者CD4＋T和NK细胞水平术前术后差异均有统计学意义（P＜0．05），但2组组间差异无统计学意义（P＞0．05）；CD8＋T在微创组术前术后的水平差异无统计学意义（P＞0．05），但术后7 d CD8＋T含量值2组组间差异有统计学意义（ P＜0．05）。结论微创手术对肺癌患者的免疫功能有很好的保护作用，可减轻患者的免疫功能的抑制。
목적：탐토미창수술대폐암환자면역공능적영향。방법장168례비소세포폐암환자，근거치료방식불동분위미창조화전통조，비교2조환자적술전、술후12h화72h적세포염성인자수평화술전、술후2d화7d 면역세포함량。결과여술전상비，술후2조환자각항세포염성인자적함량균명현제고，차차이구유통계학의의（ P＜0．05）。술후IL-6，IL-2R，CRP적함량조간적차이무통계학의의（P＞0．05）。 SAA수평술후12 h후조간차이유통계학의의（P＜0．05）。2조환자CD4＋T화NK세포수평술전술후차이균유통계학의의（P＜0．05），단2조조간차이무통계학의의（P＞0．05）；CD8＋T재미창조술전술후적수평차이무통계학의의（P＞0．05），단술후7 d CD8＋T함량치2조조간차이유통계학의의（ P＜0．05）。결론미창수술대폐암환자적면역공능유흔호적보호작용，가감경환자적면역공능적억제。
Objective To investigate the effect of minimally invasive operation on immune function of patients with lung cancer .Methods 168 patients with non-small cell lung cancer ,were divided into the minimally invasive group and the traditional group according to the different treatment methods .The preoperative and postoperative 2 d and 7 d immune cells level , and the preoperative and postoperative 12 h and 72 h cell inflammatory factor levels between the 2 groups were compared .Results Com-pared with the preoperative ,the cells inflammatory indicators significantly increased after the operation .The difference was statisti-cally significant (P<0.05);IL-6,IL-2R,CRP content between the 2 groups had no statistically significant difference (P >0.05);SAA levels 12 h after surgery between the 2 groups was statistically significant (P<0.05);The level of CD4 +T and NK cells before and after the operation had statistical difference ( P<0.05);the difference between the two groups was not statistical-ly significant (P>0.05);there was no significant difference in the level of CD 8 +T in the minimally invasive group before and af-ter the operation (P>0.05),7 d after operation CD8 +T content between the 2 groups has statistical significance (P<0.05). Conclusion Minimally invasive operation has protective effects on immune function of patients with lung cancer ,and it can alle-viate the inhibition of immune function in patients .