CAJ | 학술논문

目的：比较不同分期的宫颈癌患者的免疫功能状况，研究两者之间的相关性。方法将0～Ⅳ期宫颈患者患者（观察组）共70例，与同期健康女性（对照组）60例纳入研究，比较2组患者外周血中T淋巴细胞和NK细胞数量。结果宫颈癌患者外周血中的CD3＋、CD3＋CD4＋和NK细胞数量以及CD3＋CD4＋/CD3＋CD8＋比值均低于对照组，差异有统计学意义（ P＜0．05）。宫颈癌患者分期和T细胞亚群及NK细胞数量有相关性（ P＜0．05）。结论宫颈癌患者存在免疫功能下降的状况，并且分期越晚免疫功能越差，同时T细胞亚群数量及比例、NK细胞数量可以作为检测宫颈癌患者免疫功能的指标。
목적：비교불동분기적궁경암환자적면역공능상황，연구량자지간적상관성。방법장0～Ⅳ기궁경환자환자（관찰조）공70례，여동기건강녀성（대조조）60례납입연구，비교2조환자외주혈중T림파세포화NK세포수량。결과궁경암환자외주혈중적CD3＋、CD3＋CD4＋화NK세포수량이급CD3＋CD4＋/CD3＋CD8＋비치균저우대조조，차이유통계학의의（ P＜0．05）。궁경암환자분기화T세포아군급NK세포수량유상관성（ P＜0．05）。결론궁경암환자존재면역공능하강적상황，병차분기월만면역공능월차，동시T세포아군수량급비례、NK세포수량가이작위검측궁경암환자면역공능적지표。
Objective To study the immune function of cervical cancer patients of different clinical stages .Methods 70 patients of different clinical stages of cervical cancer (observation group) and 60 healthy women (control group) were collect-ed.The number of peripheral T lymphocytes and NK cells were compared between the 2 groups.Results The number of CD3+, CD3+CD4+and NK cells ,and CD3+CD4+/CD3+CD8+in the observation group were significantly lower than those of the control group (P<0.05).Clinical stage of patients with cervical cancer was correlated with the number of T lymphocyte subsets and NK cells (P<0.05).Conclusion Patients with cervical cancer has worse immune function ,and immune function worsens with advanced clinical stages .The number and ratio of T lymphocyte subsets and the number of NK cells can be used as indicators for detecting immune function of patients with cervical cancer .