CAJ | 학술논문

目的：探讨术前血小板/淋巴细胞比值（ PLR）对老年原发性结直肠癌预后的影响。方法回顾性分析57例老年原发性结直肠癌患者的临床资料，根据患者血小板/淋巴细胞比值分为低PLR组（＜250）41例和高PLR组（≥250）16例，分析2组患者的PLR及其它因素与患者5年生存率的相关性。结果高PLR组患者的5年生存率明显低于低PLR组（P＜0．05）；此外患者年龄、肿瘤位置、肿瘤分期、淋巴结转移、肿瘤浸润程度及分化程度等对患者的5年生存率亦有影响（P＜0．05）。肿瘤分期、淋巴结转移、肿瘤浸润程度及分化程度是影响患者预后的独立危险因素（P＜0．05）。结论术前血小板/淋巴细胞比值对老年原发性结直肠癌预后评估具有临床价值，高PLR提示有预后不良的可能。
목적：탐토술전혈소판/림파세포비치（ PLR）대노년원발성결직장암예후적영향。방법회고성분석57례노년원발성결직장암환자적림상자료，근거환자혈소판/림파세포비치분위저PLR조（＜250）41례화고PLR조（≥250）16례，분석2조환자적PLR급기타인소여환자5년생존솔적상관성。결과고PLR조환자적5년생존솔명현저우저PLR조（P＜0．05）；차외환자년령、종류위치、종류분기、림파결전이、종류침윤정도급분화정도등대환자적5년생존솔역유영향（P＜0．05）。종류분기、림파결전이、종류침윤정도급분화정도시영향환자예후적독립위험인소（P＜0．05）。결론술전혈소판/림파세포비치대노년원발성결직장암예후평고구유림상개치，고PLR제시유예후불량적가능。
Objective To investigate the effect of preoperative platelet/lymphocyte ratio ( PLR) on prognosis of primary colorectal cancer in elderly patients .Methods Clinical data of 57 cases of elderly patients with primary colorectal cancer re-ceived resection was retrospectively analyzed .According to platelet/lymphocyte ratio , patients were divided into low PLR group ( <250) 41 cases and high PLR group (≥250) 16 cases,relationship between 5-year survival rate and PLR and other factors of the 2 groups were analyzed .Results 5-year survival rate of the high PLR group was significantly lower than that of the low PLR group (P<0.05);age,tumor location,tumor stage,lymph node metastasis,tumor invasion and differentiation,were related with 5-year survival rate (P<0.05).Tumor stage,lymph node metastasis,tumor invasion and differentiation were independent risk fac-tors for prognosis(P<0.05).Conclusion Preoperative platelet/lymphocyte ratio has clinical value for assessing the prognosis of elderly patients with primary colorectal cancer ,high PLR indicates a poor prognosis .