CAJ | 학술논문

目的：探讨多种血清肿瘤标志物检测在早期宫颈癌诊断中的意义。方法将宫颈癌患者60例（均病理确诊）作为观察组；同时收集同一时期门诊体检的健康妇女60例为正常对照组。比较2组血清中鳞状细胞癌抗原（squamous cell carcinoma，SCC）、癌胚抗原（ccarcino embryonic antigen，CEA）、糖链抗原125（carbohydrate antigen 125， CA125）和糖链抗原19-9（carbohydrate antigen 19-9，CA19-9）的水平。结果观察组患者血清中肿瘤标志物SCC、CEA、CA125和CA19-9的水平均明显高于正常对照组。 SCC、CEA、CA125和CA19-9单一检测诊断宫颈癌的敏感性分别为51．67％、46．67％、56．67％、60．00％，均明显低于联合检测时诊断敏感性的86．67％。宫颈癌患者肿瘤分化越低，各肿瘤标志物的水平越高；宫颈鳞癌患者血清SCC水平明显高于宫颈鳞状上皮细胞癌患者，而宫颈鳞癌患者CEA、CA125和CA19-9水平均明显低于鳞状上皮细胞癌患者，差异均具有统计学意义（P＜0．05）。结论血清中SCC、CEA、CA125和CA19-9的水平有助于早期诊断宫颈癌，并且这些肿瘤标志物联合检测可以提高诊断敏感性，并可以提示肿瘤的病理类型和分化程度，有助于早期治疗。
목적：탐토다충혈청종류표지물검측재조기궁경암진단중적의의。방법장궁경암환자60례（균병리학진）작위관찰조；동시수집동일시기문진체검적건강부녀60례위정상대조조。비교2조혈청중린상세포암항원（squamous cell carcinoma，SCC）、암배항원（ccarcino embryonic antigen，CEA）、당련항원125（carbohydrate antigen 125， CA125）화당련항원19-9（carbohydrate antigen 19-9，CA19-9）적수평。결과관찰조환자혈청중종류표지물SCC、CEA、CA125화CA19-9적수평균명현고우정상대조조。 SCC、CEA、CA125화CA19-9단일검측진단궁경암적민감성분별위51．67％、46．67％、56．67％、60．00％，균명현저우연합검측시진단민감성적86．67％。궁경암환자종류분화월저，각종류표지물적수평월고；궁경린암환자혈청SCC수평명현고우궁경린상상피세포암환자，이궁경린암환자CEA、CA125화CA19-9수평균명현저우린상상피세포암환자，차이균구유통계학의의（P＜0．05）。결론혈청중SCC、CEA、CA125화CA19-9적수평유조우조기진단궁경암，병차저사종류표지물연합검측가이제고진단민감성，병가이제시종류적병리류형화분화정도，유조우조기치료。
Objective To study significance of several serum tumor markers in the diagnosis of early stage cervical car -cinoma .Methods 60 cases of cervical cancer patients ( proven by pathology ) was the observation group ,and 60 cases of healthy women healthy was the control group .Serum squamous cell carcinoma antigen (squamous cell carcinoma,SCC),carcinoembryonic antigen (carcinoembryonic antigen ,CEA),carbohydrate antigen 125 (carbohydrate antigen 125,CA125) and carbohydrate anti-gen 19-9 (carbohydrate antigen 19-9,CA19-9) level of the 2 groups were compared.Results Levels of serum tumor markers SCC,CEA,CA125 and CA19-9 in the observation group were significantly higher than those of the control group .Sensitivity of SCC,CEA,CA125 and CA19-9 single test in the diagnosis of cervical cancer were 51.67%,46.67%,56.67%,60.00%,all the were significantly lower than sensitivity of combined testing (86.67%).The lower the differentiation of cervical cancer tumor ,the higher the level of tumor markers;serum level of SCC in cervical squamous cell carcinoma was significantly higher than that of squamous cell carcinoma of the cervix ,while CEA ,CA125 and CA19-9 in cervical squamous cell carcinoma was significantly lower than that of squamous cell carcinoma of the cervix ,the differences were statistically significant (P<0.05).Conclusion Serum SCC,CEA,CA125 and CA19-9 level is helpful in early diagnosis of cervical cancer ,and the combined detection of tumor markers can improve the sensitivity of diagnosis , and indicate pathology type and differentiation degree .It contributes to the early treat-ment .