现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
21期
2299-2301
,共3页
乳腺肿瘤%Survivin%Ki-67%免疫组化%三阴乳腺癌
乳腺腫瘤%Survivin%Ki-67%免疫組化%三陰乳腺癌
유선종류%Survivin%Ki-67%면역조화%삼음유선암
breast cancer%Survivin%Ki-67%immunohistochemistry%triple-negative breast cancer
目的：检测三阴乳腺癌组织（ TNBC）中抗凋亡蛋白Survivin和增殖细胞核抗原Ki-67表达情况并探讨其意义。方法采用免疫组化 SP法检测56例ER、PR和HER-2均为阴性的TNBC组织和30例癌旁正常乳腺组织Survivin和Ki-67的表达情况。结果 TN-BC组织中Survivin和Ki-67表达定位于细胞核，其表达率分别为62％（34/56）和70％（39/56），明显高于癌旁正常组织（P＜0．05）；56例TNBC组织中，Survivin和Ki-67蛋白在cTNM分级中Ⅲ级表达率高于Ⅰ＋Ⅱ级（P＜0．05），Survivin和Ki-67在病理分期Ⅲ＋Ⅳ期的表达率高于Ⅰ～Ⅱ期（P＜0．05），表达率与腋窝淋巴结转移呈正相关（P＜0．05），而与年龄无关（P＞0．05）。结论 Survivin和Ki-67在TNBC中呈明显高表达，与TNBC的发生、发展和转移密切相关。
目的：檢測三陰乳腺癌組織（ TNBC）中抗凋亡蛋白Survivin和增殖細胞覈抗原Ki-67錶達情況併探討其意義。方法採用免疫組化 SP法檢測56例ER、PR和HER-2均為陰性的TNBC組織和30例癌徬正常乳腺組織Survivin和Ki-67的錶達情況。結果 TN-BC組織中Survivin和Ki-67錶達定位于細胞覈，其錶達率分彆為62％（34/56）和70％（39/56），明顯高于癌徬正常組織（P＜0．05）；56例TNBC組織中，Survivin和Ki-67蛋白在cTNM分級中Ⅲ級錶達率高于Ⅰ＋Ⅱ級（P＜0．05），Survivin和Ki-67在病理分期Ⅲ＋Ⅳ期的錶達率高于Ⅰ～Ⅱ期（P＜0．05），錶達率與腋窩淋巴結轉移呈正相關（P＜0．05），而與年齡無關（P＞0．05）。結論 Survivin和Ki-67在TNBC中呈明顯高錶達，與TNBC的髮生、髮展和轉移密切相關。
목적：검측삼음유선암조직（ TNBC）중항조망단백Survivin화증식세포핵항원Ki-67표체정황병탐토기의의。방법채용면역조화 SP법검측56례ER、PR화HER-2균위음성적TNBC조직화30례암방정상유선조직Survivin화Ki-67적표체정황。결과 TN-BC조직중Survivin화Ki-67표체정위우세포핵，기표체솔분별위62％（34/56）화70％（39/56），명현고우암방정상조직（P＜0．05）；56례TNBC조직중，Survivin화Ki-67단백재cTNM분급중Ⅲ급표체솔고우Ⅰ＋Ⅱ급（P＜0．05），Survivin화Ki-67재병리분기Ⅲ＋Ⅳ기적표체솔고우Ⅰ～Ⅱ기（P＜0．05），표체솔여액와림파결전이정정상관（P＜0．05），이여년령무관（P＞0．05）。결론 Survivin화Ki-67재TNBC중정명현고표체，여TNBC적발생、발전화전이밀절상관。
Objective It is to observe the expression of Survivin and Ki -67 in human triple-negative breast cancer ( TN-BC) and approach the clinical pathological significance .Methods Using SP immunohistochemistry method , the expression of Survivin and Ki -67 in 56 cases of breast cancer tissue in patients with TNBC ( ER, PR and HER-2 were all negative ex-pression) and 30 cases of normal breast tissue adjacent cancer were examined .Results The expression of Survivin and Ki -67 in TNBC tissue was located within the nucleus .The positive expression rates of Survivin and Ki -67 were 62%(34/56) and 70%(39/56) respectively, which were much higher than that in the adjacent normal tissue (all P<0.05).In the 56 cases of TNBC, the positive expression of Survivin and Ki -67 in cTNM grade III was significantly higher than that in grade I and II (all P<0.05 ).In addition, the positive expression of Survivin and Ki -67 in stage III and IV tumors was also higher than that in stageI and II tumors (P<0.05).Furthermore, the expression of Survivin and Ki -67 were associated with axillary lymph node metastasis (P<0.05), and were not related with ages (P>0.05).Conclusion Survivin and Ki-67 are highly expressed in TNBC and their expressions were closely related with the occurrence , development and metastasis of TNBC .
