CAJ | 학술논문

目的：探讨P-cadherin、34βE12在乳腺导管内增生性病变和浸润性导管癌中的表达与意义。方法采用免疫组织化学S-P法观察P-cadherin、34βE12在各组病变中的表达。结果 P-cadherin的表达在乳腺普通型导管增生（UDH）与导管原位癌（DICS）组、UDH与浸润性导管癌（IDC）组、平坦型上皮非典型增生（FEA）与IDC组、非典型性导管增生（ADH）与 IDC组的差异有统计学意义（ P ＜0．05）；34βE12的表达在 UDH 与 FEA组、UDH与ADH组、UDH与DICS组、UDH与IDC组的差异有统计学意义（ P ＜0．05）。结论 P-cadherin、34βE12可应用于乳腺导管内增生性病变和浸润性导管癌的鉴别诊断。
목적：탐토P-cadherin、34βE12재유선도관내증생성병변화침윤성도관암중적표체여의의。방법채용면역조직화학S-P법관찰P-cadherin、34βE12재각조병변중적표체。결과 P-cadherin적표체재유선보통형도관증생（UDH）여도관원위암（DICS）조、UDH여침윤성도관암（IDC）조、평탄형상피비전형증생（FEA）여IDC조、비전형성도관증생（ADH）여 IDC조적차이유통계학의의（ P ＜0．05）；34βE12적표체재 UDH 여 FEA조、UDH여ADH조、UDH여DICS조、UDH여IDC조적차이유통계학의의（ P ＜0．05）。결론 P-cadherin、34βE12가응용우유선도관내증생성병변화침윤성도관암적감별진단。
Objective To investigate the expression and significance of P-cadherin ,34βE12 in intraductal proliferative lesions and invasive cancer of breast .Methods The S-P immunohistochemical method was used to ob-serve the expression of P-cadherin ,34βE12 in each lesion.Results The expression of P-cadherin has statistically differences in UDH and DICS group ,UDH and IDC group ,FEA and IDC group ,ADH and IDC group ( P <0.05) ,respectively .The expression of 34βE12 has statistical differences in UDH and FEA group ,UDH and ADH group ,UDH and DICS group ,UDH and IDC group ( P <0.05) ,respectively .Conclusion P-cadherin ,34βE12 can be used in differential diagnosis of intraductal proliferative lesions and invasive ductal cancer of breast.