CAJ | 학술논문

目的：观察氨氯地平联合厄贝沙坦治疗原发性高血压的疗效。方法选择来我院治疗的原发性高血压100例为研究对象，随机分为研究组和对照组各50例，研究组予厄贝沙坦（安博维）150 mg/d口服，氨氯地平（络活喜）5 mg/d口服；对照组予厄贝沙坦150 mg/d口服，疗程8周。结果（1）两组患者的SBP、DBP治疗后均较治疗前明显降低，且治疗后研究组和对照组患者的SBP、DBP组间比较，差异有统计学意义。（2）研究组和对照组患者治疗后的总有效率分别为95.0%、80.0%，差异有统计学意义（χ2=4.923，P＜0.05）。（3）不良反应：两组患者治疗期间肝肾功能未见明显异常。结论氨氯地平联合厄贝沙坦治疗原发性高血压疗效显著，且安全性好，值得广泛推广和应用。
목적：관찰안록지평연합액패사탄치료원발성고혈압적료효。방법선택래아원치료적원발성고혈압100례위연구대상，수궤분위연구조화대조조각50례，연구조여액패사탄（안박유）150 mg/d구복，안록지평（락활희）5 mg/d구복；대조조여액패사탄150 mg/d구복，료정8주。결과（1）량조환자적SBP、DBP치료후균교치료전명현강저，차치료후연구조화대조조환자적SBP、DBP조간비교，차이유통계학의의。（2）연구조화대조조환자치료후적총유효솔분별위95.0%、80.0%，차이유통계학의의（χ2=4.923，P＜0.05）。（3）불량반응：량조환자치료기간간신공능미견명현이상。결론안록지평연합액패사탄치료원발성고혈압료효현저，차안전성호，치득엄범추엄화응용。
Objective To investigate the efficacy of irbesartan combined amlodipine in treatment of essential hyperten-sion. Methods A total of 100 cases essential hypertension in our hospital were randomly divided into study group and the control group, 50 cases in each group, the study group were given irbesartan(Upway) 150mg/d orally, amlodipine (Norvasc)5 mg/d orally; control group were given 150 mg/d orally. The total treatment course were 8 weeks. Results (1)The study group and the control group of patients with SBP, DBP after treatment was significantly lower than before treatment, after treatment, SBP and DBP of study group was improved than the control group more significant, the dif-ference was statistically significant. (2)The total efficiency of study group and the control group respectively was 95.0%, and 80.0%, the difference was statistically significant between the two groups (χ2=4.923, P<0.05) after treatment. (3)Ad-verse reactions: During the two groups of patients showed no abnormal kidney function. Conclusion Amlodipine com-bined with irbesartan in treatment of essential hypertension has significant effect and safety, should be popularized and applied.