中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
20期
44-46
,共3页
自凝刀射频消融术%米非司酮%子宫肌瘤%性激素
自凝刀射頻消融術%米非司酮%子宮肌瘤%性激素
자응도사빈소융술%미비사동%자궁기류%성격소
Radiofrequency ablation%Mifepristone%Uterine myoma%Sex hormone
目的:探讨自凝刀射频消融术联合米非司酮治疗子宫肌瘤的疗效及对性激素水平的影响。方法选取我院子宫肌瘤患者126例随机分为两组,研究组63例行射频消融术治疗后口服米非司酮;对照组63例单纯行射频消融术治疗,比较两组患者治疗疗效及对促卵泡激素(FSH)、黄体生成素(LH)、孕酮(P)、雌二醇(E2)等性激素水平的影响差异。结果经自凝刀射频消融术联合米非司酮治疗后,研究组患者的治疗有效率高达98.41%,显著高于对照组,且两组FSH、LH、P、E2水平均具有显著性差异(P均<0.05),其中P、E2显著低于对照组;治疗后研究组子宫肌瘤体积较治疗前显著减小,且明显小于对照组,其瘤体缩小率也明显高于对照组(P均<0.05);研究组患者药物不良反应轻,仅1例出现恶心、2例出现轻度头晕症状,两组患者不良反应率差异无统计学意义(P>0.05)。结论自凝刀射频消融术联合米非司酮治疗子宫肌瘤疗效显著,其作用机制可能是通过降低血清P、E2水平及缩小肌瘤体积而使子宫肌瘤消失。
目的:探討自凝刀射頻消融術聯閤米非司酮治療子宮肌瘤的療效及對性激素水平的影響。方法選取我院子宮肌瘤患者126例隨機分為兩組,研究組63例行射頻消融術治療後口服米非司酮;對照組63例單純行射頻消融術治療,比較兩組患者治療療效及對促卵泡激素(FSH)、黃體生成素(LH)、孕酮(P)、雌二醇(E2)等性激素水平的影響差異。結果經自凝刀射頻消融術聯閤米非司酮治療後,研究組患者的治療有效率高達98.41%,顯著高于對照組,且兩組FSH、LH、P、E2水平均具有顯著性差異(P均<0.05),其中P、E2顯著低于對照組;治療後研究組子宮肌瘤體積較治療前顯著減小,且明顯小于對照組,其瘤體縮小率也明顯高于對照組(P均<0.05);研究組患者藥物不良反應輕,僅1例齣現噁心、2例齣現輕度頭暈癥狀,兩組患者不良反應率差異無統計學意義(P>0.05)。結論自凝刀射頻消融術聯閤米非司酮治療子宮肌瘤療效顯著,其作用機製可能是通過降低血清P、E2水平及縮小肌瘤體積而使子宮肌瘤消失。
목적:탐토자응도사빈소융술연합미비사동치료자궁기류적료효급대성격소수평적영향。방법선취아원자궁기류환자126례수궤분위량조,연구조63례행사빈소융술치료후구복미비사동;대조조63례단순행사빈소융술치료,비교량조환자치료료효급대촉란포격소(FSH)、황체생성소(LH)、잉동(P)、자이순(E2)등성격소수평적영향차이。결과경자응도사빈소융술연합미비사동치료후,연구조환자적치료유효솔고체98.41%,현저고우대조조,차량조FSH、LH、P、E2수평균구유현저성차이(P균<0.05),기중P、E2현저저우대조조;치료후연구조자궁기류체적교치료전현저감소,차명현소우대조조,기류체축소솔야명현고우대조조(P균<0.05);연구조환자약물불량반응경,부1례출현악심、2례출현경도두훈증상,량조환자불량반응솔차이무통계학의의(P>0.05)。결론자응도사빈소융술연합미비사동치료자궁기류료효현저,기작용궤제가능시통과강저혈청P、E2수평급축소기류체적이사자궁기류소실。
Objective To study the efficacy on hormone levels of radiofrequency ablation combined with mifepristone in the treatment of uterine fibroids. Methods A total of 126 patients in our hospital of uterine fibroids were divided into two groups, study group with 63 cases were given radiofrequency ablation therapy after mifepristone orally; Control group with 63 cases were given underwent radiofrequency ablation in the treatment of patients , the efficacy and sex hormones of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), estradiol (E2) were compared. Results After radiofrequency ablation combined with mifepristone treatment , clinical efficacy rate was 98.41%, significantly higher than the control group, and FSH, LH, P, E2 levels of two groups were significantly different (P<0.05), in which P, E2 were significantly lower than the control group after treatment, the study group;uterine fibroid volume than before treatment significantly reduced , and obviously less than that of the control group , the tumor size was also higher than that in control group (P < 0.05); study group patients with adverse drug reaction light, only 1 cases of nausea, 2 cases of mild dizziness symptoms, patients in the two groups are no adverse reaction rate shows no statistical difference between significance(P>0.05). Conclusion The efficacy of radiofrequency ablation combined with mifepristone in the treatment of uterine fibroids significantly , and its mechanism may be through decreasing serum P, E2 levels and reducing myoma volume of uterine fibroids disappeared.