CAJ | 학술논문

目的：探讨十二指肠乳头癌组织中碳酸酐酶Ⅸ（CAⅨ）、桩蛋白与生长抑素受体（SSTR）的表达及临床意义。方法应用免疫组化方法检测87例十二指肠乳头癌组织中碳酸酐酶Ⅸ（CAⅨ）、桩蛋白与生长抑素受体（SSTR）的表达。结果87例十二指肠乳头癌中，CAⅨ阳性率达71.3%（62/87），桩蛋白阳性率达74.7%（65/87），显著高于其他两组（P＜0.05）。而生长抑素受体阳性率48.2%（42/87），显著低于其他两组（P＜0.05）。且低分化组的十二指肠乳头癌的CAⅨ阳性率、桩蛋白阳性率、SSTR阳性率与中、高分化组比较，差异显著（P＜0.05）。而M1期的十二指肠乳头癌的CAⅨ阳性率、桩蛋白阳性率、SSTR阳性率与M0期比较，差异显著（P＜0.05）。结论碳酸酐酶Ⅸ（CAⅨ）、生长抑素受体（SSTR）及桩蛋白三者与十二指肠乳头癌的发生、发展及转移密切相关，可以作为诊断早期肿瘤的重要指标之一，也可以用于评价肿瘤的发展及预后。
목적：탐토십이지장유두암조직중탄산항매Ⅸ（CAⅨ）、장단백여생장억소수체（SSTR）적표체급림상의의。방법응용면역조화방법검측87례십이지장유두암조직중탄산항매Ⅸ（CAⅨ）、장단백여생장억소수체（SSTR）적표체。결과87례십이지장유두암중，CAⅨ양성솔체71.3%（62/87），장단백양성솔체74.7%（65/87），현저고우기타량조（P＜0.05）。이생장억소수체양성솔48.2%（42/87），현저저우기타량조（P＜0.05）。차저분화조적십이지장유두암적CAⅨ양성솔、장단백양성솔、SSTR양성솔여중、고분화조비교，차이현저（P＜0.05）。이M1기적십이지장유두암적CAⅨ양성솔、장단백양성솔、SSTR양성솔여M0기비교，차이현저（P＜0.05）。결론탄산항매Ⅸ（CAⅨ）、생장억소수체（SSTR）급장단백삼자여십이지장유두암적발생、발전급전이밀절상관，가이작위진단조기종류적중요지표지일，야가이용우평개종류적발전급예후。
Objective To investigate the expression and significance of detecting carbonic anhydrase Ⅸ(CAⅨ), pax-illin (paxillin) and somatostatin receptors (SSTR) in patients with duodenal carcinoma. Methods The immunohisto-chemistry was used to detect 87 cases of duodenal carcinoma carbonic anhydrase Ⅸ (CA Ⅸ), paxillin (paxillin) and somatostatin receptors (SSTR) expression. Results Among 87 cases of duodenal cancer, CA Ⅸ positive rate of 71.3%(62/87), paxillin positive rate of 74.7% (65/87), was significantly higher than other groups (P<0.05). The rate of so-matostatin receptor-positive rate of 48.2%(42/87),was significantly lower than than other groups (P<0.05). And the positive rate of duodenal CA Ⅸ poorly differentiated cancer group, the positive rate of protein pile, SSTR-positive rate compared with the well-differentiated group (P<0.05). The positive rate of M1 CA Ⅸ of duodenal papilla cancer, the positive rate of paxillin, SSTR-positive rate compared with M0 stage(P<0.05). Conclusion Carbonic anhydrase Ⅸ(CAⅨ), occurrence, development and metastasis of somatostatin receptor (SSTR) and paxillin and three closely related duodenal cancer, can serve as an important indicator of early diagnosis of cancer, can also be used to assess tumor development and prognosis.