造血干细胞采集前后亲缘及非亲缘供者心理健康状态比较
조혈간세포채집전후친연급비친연공자심리건강상태비교
Mental health status of relative donors versus unrelated donors before and after hematopoietic stem cell collection
  • 万方数据
    中国组织工程研究 중국조직공정연구
    Journal of Clinical Rehabilitative Tissue Engineering Research
    2014年 28期 4524-4529 ,共6页

    侯艳红%赵淑燕%齐秦甲子%刘丽辉%陈晓菲%施兵%朱玲%徐晨%贾瑞铭%王蔚蔚%杨静%梁永清%谭亦%李福兴%叶丽萍

    후염홍%조숙연%제진갑자%류려휘%진효비%시병%주령%서신%가서명%왕위위%양정%량영청%담역%리복흥%협려평

    干细胞%移植%造血干细胞移植%非亲缘%亲缘%供者%情绪%心理%恐惧%焦虑%抑郁 榦細胞%移植%造血榦細胞移植%非親緣%親緣%供者%情緒%心理%恐懼%焦慮%抑鬱
    간세포%이식%조혈간세포이식%비친연%친연%공자%정서%심리%공구%초필%억욱
    hematopoietic stem celltransplantation%stress,psychological%fear%anxiety
    背景：目前造血干细胞移植主要依靠在非血缘关系供者中寻找相合者。非亲缘造血干细胞捐献者的心理状态对于保证顺利完成移植，使受者得到有效治疗非常重要。目的：比较亲缘及非亲缘供者造血干细胞采集前后心理及生理健康状态。方法：分别在入院时，采集前(1 d)，采集后(一两天)，1个月后回访4个时间点对亲缘与非亲缘供者的心理状态(SCL-90症状自评量表评分)及一般生理指标(体温，呼吸，脉搏，血压)进行评估比较。结果与结论：在入院时，亲缘与非亲缘供者的心理健康水平差异无显著性意义(P>0.05)；而在采集前、采集后，非亲缘供者的SCL-90总分、强迫、抑郁、焦虑、敌对、恐惧分值高于亲缘供者(P <0.05)；1个月后回访，大多数分值差异无显著性意义(P>0.05)。非亲缘和亲缘供者的生理指标平稳，但在采集前和采集后2个时间点，两组供者呼吸和收缩压差异有显著性意义。提示非亲缘供者在采集过程中的心理负荷较高，应给予针对性情绪疏导指导和心理防护。
    배경：목전조혈간세포이식주요의고재비혈연관계공자중심조상합자。비친연조혈간세포연헌자적심리상태대우보증순리완성이식，사수자득도유효치료비상중요。목적：비교친연급비친연공자조혈간세포채집전후심리급생리건강상태。방법：분별재입원시，채집전(1 d)，채집후(일량천)，1개월후회방4개시간점대친연여비친연공자적심리상태(SCL-90증상자평량표평분)급일반생리지표(체온，호흡，맥박，혈압)진행평고비교。결과여결론：재입원시，친연여비친연공자적심리건강수평차이무현저성의의(P>0.05)；이재채집전、채집후，비친연공자적SCL-90총분、강박、억욱、초필、활대、공구분치고우친연공자(P <0.05)；1개월후회방，대다수분치차이무현저성의의(P>0.05)。비친연화친연공자적생리지표평은，단재채집전화채집후2개시간점，량조공자호흡화수축압차이유현저성의의。제시비친연공자재채집과정중적심리부하교고，응급여침대성정서소도지도화심리방호。
    BACKGROUND:Currently, hematopoietic stem celltransplantation mainly depends on unrelated donors. Mental state of the unrelated donors is very important to ensure the successful celltransplantation. OBJECTIVE:To compare mental and physical health status of relative and unrelated donors during the hematopoietic stem cellcol ection. METHODS:We compared the mental (Symptom Checklist-90) and physical (temperature, breath, pulse, and blood pressure) health status of relative and unrelated donors at admission, 1 day before cellcol ection, and 1-2 days after cellcol ection.RESULTS AND CONCLUSION:At admission, there was no difference in the mental health status of relative and unrelated donors (P>0.05), while the scores on Symptom Checklist-90 were significantly higher in the unrelated donors than the relative donors, including total score, forced, depression, anxiety, hostility, and fear (P<0.05). The physical signs were steady in the unrelated and relative donors, but the difference in breath and systolic blood pressure was of great significance before and after cellcol ection in the two groups. These findings indicate that during cellcol ection, the unrelated donors exhibit heavier mental load than the relative donors, and psychological counseling and health guidance are necessary.
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