中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
10期
840-842
,共3页
褚琳%陈陵霞%苗懿德%刘杰%郏蓉%魏雅楠
褚琳%陳陵霞%苗懿德%劉傑%郟蓉%魏雅楠
저림%진릉하%묘의덕%류걸%겹용%위아남
前列腺增生%胰岛素抵抗%空腹胰岛素
前列腺增生%胰島素牴抗%空腹胰島素
전렬선증생%이도소저항%공복이도소
Prostatic hyperplasia%Insuline resistance%Fasting insulin
目的 探讨胰岛素抵抗与良性前列腺增生(BPH)发生发展的相关性. 方法 纳入我院老年科住院的男性患者150例.测量血压、身高、体质量、计算体质指数(BMI).并检测空腹胰岛素(FINS)、空腹血糖、胰岛素抵抗指数(HOMA-IR)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和前列腺特异性抗原(PSA).超声测量及计算前列腺体积(PV). 结果 胰岛素抵抗组(40例)患者PV和PV年增长率明显大于胰岛素敏感组(110例)患者(t=2.91,3.71;均P＜0.01).随着患者FINS、HOMA-IR、PSA的增加,PV增大(t值分别为-3.02、-2.88、-2.84;均P＜0.05).PV与胰岛素抵抗、FINS、PSA呈正相关(r分别为0.16,0.16,0.35;均P＜0.05);PV年增长率与胰岛素抵抗、FINS、PSA、BMI成正相关(r分别为0.22,0.21,0.24,0.19;均P＜0.05).结论 胰岛素抵抗和高FINS是BPH发生发展的危险因素.
目的 探討胰島素牴抗與良性前列腺增生(BPH)髮生髮展的相關性. 方法 納入我院老年科住院的男性患者150例.測量血壓、身高、體質量、計算體質指數(BMI).併檢測空腹胰島素(FINS)、空腹血糖、胰島素牴抗指數(HOMA-IR)、總膽固醇、甘油三酯、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇和前列腺特異性抗原(PSA).超聲測量及計算前列腺體積(PV). 結果 胰島素牴抗組(40例)患者PV和PV年增長率明顯大于胰島素敏感組(110例)患者(t=2.91,3.71;均P＜0.01).隨著患者FINS、HOMA-IR、PSA的增加,PV增大(t值分彆為-3.02、-2.88、-2.84;均P＜0.05).PV與胰島素牴抗、FINS、PSA呈正相關(r分彆為0.16,0.16,0.35;均P＜0.05);PV年增長率與胰島素牴抗、FINS、PSA、BMI成正相關(r分彆為0.22,0.21,0.24,0.19;均P＜0.05).結論 胰島素牴抗和高FINS是BPH髮生髮展的危險因素.
목적 탐토이도소저항여량성전렬선증생(BPH)발생발전적상관성. 방법 납입아원노년과주원적남성환자150례.측량혈압、신고、체질량、계산체질지수(BMI).병검측공복이도소(FINS)、공복혈당、이도소저항지수(HOMA-IR)、총담고순、감유삼지、저밀도지단백담고순、고밀도지단백담고순화전렬선특이성항원(PSA).초성측량급계산전렬선체적(PV). 결과 이도소저항조(40례)환자PV화PV년증장솔명현대우이도소민감조(110례)환자(t=2.91,3.71;균P＜0.01).수착환자FINS、HOMA-IR、PSA적증가,PV증대(t치분별위-3.02、-2.88、-2.84;균P＜0.05).PV여이도소저항、FINS、PSA정정상관(r분별위0.16,0.16,0.35;균P＜0.05);PV년증장솔여이도소저항、FINS、PSA、BMI성정상관(r분별위0.22,0.21,0.24,0.19;균P＜0.05).결론 이도소저항화고FINS시BPH발생발전적위험인소.
Objective To evaluate the relationship between insulin resistance and benign prostatic hyperplasia (BPH).Methods Totally 150 male patient from the Department of Geriatrics in Peking University Hospital were included in this study.Blood pressure,body weight,body height,body mass index (BMI) were measured and calculated.Biochemical analyses including serum fasting levels of insulin(FINS),glucose,total cholesterol,triglycerides,low-density lipoprotein cholesterol,high density lipoprotein cholesterol,and prostate-specific antigen (PSA) were performed.Total prostate volume (PV) were measured by ultrasound.Results PV and annual prostate growth rate were more increased in insulin resistance group(40 cases) compared with insulin sensitivity group(110 cases) (t=2.91,3.71 respectively,both P＜0.01).Along with the levels of FINS,HOMA-IR and PSA were increased,the prostate volume was enhanced (t=-3.02,-2.88,-2.84 respectively;all P ＜0.05).PV was positively correlated with insulin resistance,serum fasting insulin and PSA (r=0.16,0.16,0.35;all P＜0.05),while annual prostate growth rate was positively related with insulin resistance,serum fasting insulin,PSA and BMI (r =0.22,0.21,0.24,0.19 ; all P ＜ 0.05).Conclusions Insulin resistance and fasting insulin plays roles in the pathogenesis of prostatic hyperplasia.
