中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2014年
6期
435-436
,共2页
戴维维%高丽娟%刘楠%聂振华
戴維維%高麗娟%劉楠%聶振華
대유유%고려연%류남%섭진화
掌跖脓疱病%白芍总苷%问卷%治疗结果
掌蹠膿皰病%白芍總苷%問捲%治療結果
장척농포병%백작총감%문권%치료결과
Palmoplantar pustulosis%Total glucosides of paeony%Questionnaires%Treatment outcome
目的 探讨掌跖脓疱病发病因素及白芍总苷治疗的疗效.方法 采用问卷的形式调查掌跖脓疱病患者的临床资料,对入选患者进行斑贴试验并随机等分为观察组和对照组,观察组给予口服白芍总苷胶囊,每日3次,每次0.6 g;对照组给予口服雷公藤多苷片,每日3次,每次20 mg,同时两组均外用糠酸莫米松乳膏,每日1次,观察4周和8周的疗效和不良反应.结果 入选90例掌跖脓疱病患者中,男女之比为1∶1.64,吸烟患者占42.22％(38例),以感染为诱发因素的患者占26.67％(23例).斑贴试验中重铬酸钾和硫酸镍的阳性率最为显著.治疗4周后,对照组总有效率高于观察组(64.44％比40.00％,x2=5.388,P＜0.05),治疗8周后,两组总有效率差异无统计学意义(88.89％比80.00％,x2=1.353,P＞0.05),不良反应发生率差异亦无统计学意义(17.78％比11.11％,x2=0.809,P＞0.05).结论 吸烟在掌跖脓疱病的发病中可能起一定作用,感染是主要的诱发因素.白芍总苷联合糠酸莫米松乳膏治疗掌跖脓疱病有效.
目的 探討掌蹠膿皰病髮病因素及白芍總苷治療的療效.方法 採用問捲的形式調查掌蹠膿皰病患者的臨床資料,對入選患者進行斑貼試驗併隨機等分為觀察組和對照組,觀察組給予口服白芍總苷膠囊,每日3次,每次0.6 g;對照組給予口服雷公籐多苷片,每日3次,每次20 mg,同時兩組均外用糠痠莫米鬆乳膏,每日1次,觀察4週和8週的療效和不良反應.結果 入選90例掌蹠膿皰病患者中,男女之比為1∶1.64,吸煙患者佔42.22％(38例),以感染為誘髮因素的患者佔26.67％(23例).斑貼試驗中重鉻痠鉀和硫痠鎳的暘性率最為顯著.治療4週後,對照組總有效率高于觀察組(64.44％比40.00％,x2=5.388,P＜0.05),治療8週後,兩組總有效率差異無統計學意義(88.89％比80.00％,x2=1.353,P＞0.05),不良反應髮生率差異亦無統計學意義(17.78％比11.11％,x2=0.809,P＞0.05).結論 吸煙在掌蹠膿皰病的髮病中可能起一定作用,感染是主要的誘髮因素.白芍總苷聯閤糠痠莫米鬆乳膏治療掌蹠膿皰病有效.
목적 탐토장척농포병발병인소급백작총감치료적료효.방법 채용문권적형식조사장척농포병환자적림상자료,대입선환자진행반첩시험병수궤등분위관찰조화대조조,관찰조급여구복백작총감효낭,매일3차,매차0.6 g;대조조급여구복뢰공등다감편,매일3차,매차20 mg,동시량조균외용강산막미송유고,매일1차,관찰4주화8주적료효화불량반응.결과 입선90례장척농포병환자중,남녀지비위1∶1.64,흡연환자점42.22％(38례),이감염위유발인소적환자점26.67％(23례).반첩시험중중락산갑화류산얼적양성솔최위현저.치료4주후,대조조총유효솔고우관찰조(64.44％비40.00％,x2=5.388,P＜0.05),치료8주후,량조총유효솔차이무통계학의의(88.89％비80.00％,x2=1.353,P＞0.05),불량반응발생솔차이역무통계학의의(17.78％비11.11％,x2=0.809,P＞0.05).결론 흡연재장척농포병적발병중가능기일정작용,감염시주요적유발인소.백작총감연합강산막미송유고치료장척농포병유효.
Objective To analyze causative factors for and therapeutic effect of total glucosides of paeony (TGP) on palmoplantar pustulosis (PPP).Methods Ninety patients with PPP were recruited in this study.A questionnaire survey was carried out to collect clinical data from these patients,and a patch test to identify contact allergens for these patients.All the patients were randomly divided into two groups:observation group treated with TGP capsule 0.6 g thrice a day,and control group treated with tripterygium glycosides tablets 20 mg thrice a day.Both groups topically applied mometasone furoate cream once a day.The efficacy and side effects were evaluated 4 and 8 weeks after initiation of treatment.Results Of the 90 patients,the ratio of male to female was 1 ∶ 1.64,smokers amounted to 42.22％,and 23 (26.67％) reported a history of infection before the onset of PPP.As the patch test showed,potassium dichromate and nickel sulfate were the most common contact allergens in these patients.The response rate was significantly higher in the observation group than in the control group after 4 weeks of treatment (64.44％ vs.40.00％,x2 =5.388,P ＜ 0.05),but similar between the two groups after 8 weeks of treatment (88.89％ vs.80.00％,x2 =1.353,P ＞ 0.05).No significant difference was observed in the occurrence of adverse reactions between the two groups (17.78％ vs.11.11％,x2 =0.809,P ＞ 0.05).Conclusions Smoking may play a certain role in the development of PPP,and infection seems to be a primary inducing factor.TGP combined with mometasone furoate cream is effective for the treatment of PPP.
