实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
11期
1826-1829
,共4页
常崇甫%翁岚东%郭培培%林春水
常崇甫%翁嵐東%郭培培%林春水
상숭보%옹람동%곽배배%림춘수
术后咽喉痛%气管内插管%氯胺酮%meta分析
術後嚥喉痛%氣管內插管%氯胺酮%meta分析
술후인후통%기관내삽관%록알동%meta분석
Postoperative sore throat%Endotracheal intubation%Ketamine%Meta-analysis
目的：评价局部应用氯胺酮对气管内插管术后咽喉痛（postoperative sore throat， POST）的效果及安全性。方法：网络检索相关中英文数据库，选取局部应用氯胺酮预防POST的临床文献。采用Stata 12．0软件完成Meta分析，计算POST相对危险度（risk ratio， RR）和95％可信区间（confidence interval， CI）。结果：共纳入7项研究，490例患者。以固定效应模型合并统计量，结果显示：与对照组相比，局部应用氯胺酮组的术后0～1 h，4 h及24 h咽喉痛的发生率显著降低，RR分别为0．61（95％CI 0．47～0．79，P＜0．001），0．55（95％CI 0．43～0．71，P＜0．001）和0．48（95％CI 0．34～0．66，P＜0．001）。纳入的文献均未观察到与局部应用氯胺酮相关的不良反应。结论：局部应用氯胺酮能安全有效地降低POST的发生率，效果可达24 h。
目的：評價跼部應用氯胺酮對氣管內插管術後嚥喉痛（postoperative sore throat， POST）的效果及安全性。方法：網絡檢索相關中英文數據庫，選取跼部應用氯胺酮預防POST的臨床文獻。採用Stata 12．0軟件完成Meta分析，計算POST相對危險度（risk ratio， RR）和95％可信區間（confidence interval， CI）。結果：共納入7項研究，490例患者。以固定效應模型閤併統計量，結果顯示：與對照組相比，跼部應用氯胺酮組的術後0～1 h，4 h及24 h嚥喉痛的髮生率顯著降低，RR分彆為0．61（95％CI 0．47～0．79，P＜0．001），0．55（95％CI 0．43～0．71，P＜0．001）和0．48（95％CI 0．34～0．66，P＜0．001）。納入的文獻均未觀察到與跼部應用氯胺酮相關的不良反應。結論：跼部應用氯胺酮能安全有效地降低POST的髮生率，效果可達24 h。
목적：평개국부응용록알동대기관내삽관술후인후통（postoperative sore throat， POST）적효과급안전성。방법：망락검색상관중영문수거고，선취국부응용록알동예방POST적림상문헌。채용Stata 12．0연건완성Meta분석，계산POST상대위험도（risk ratio， RR）화95％가신구간（confidence interval， CI）。결과：공납입7항연구，490례환자。이고정효응모형합병통계량，결과현시：여대조조상비，국부응용록알동조적술후0～1 h，4 h급24 h인후통적발생솔현저강저，RR분별위0．61（95％CI 0．47～0．79，P＜0．001），0．55（95％CI 0．43～0．71，P＜0．001）화0．48（95％CI 0．34～0．66，P＜0．001）。납입적문헌균미관찰도여국부응용록알동상관적불량반응。결론：국부응용록알동능안전유효지강저POST적발생솔，효과가체24 h。
Objective To evaluate the influence and safety of topical ketamine on postoperative sore throat following endotracheal intubation. Methods The clinical literatures concerning topical application of ketamine for the prevention of postoperative sore throat (POST) were searched from online databases. Randomized controlled trials were selected by the inclusive and exclusive criteria. Meta-analysis was conducted to assess the risk ratio(RR) of the incidence of POST and software Stata 12.0 was used in this analysis. Results Seven randomized trials involving 490 patients were included in this meta-analysis. The results of meta-analysis showed that the incidence of POST was significantly reduced in the ketamine group,with RR 0.61(95%CI 0.47~0.79,P<0.001) at 0~1 h,0.55(95%CI 0.43~0.71, P<0.001) at 4 h and 0.48 (95%CI 0.34 to 0.66, P<0.001) at 24 h after surgery. No major complications related to topical ketamine were observed. Conclusions For the patients receiving general anesthesia and endotracheal intubation, topical prophylactic application of ketamine can significantly reduce the incidence of POST without major complications.
