实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
11期
1768-1771
,共4页
分枝杆菌感染%肺/免疫学%CD4阳性T淋巴细胞%营养不良
分枝桿菌感染%肺/免疫學%CD4暘性T淋巴細胞%營養不良
분지간균감염%폐/면역학%CD4양성T림파세포%영양불량
Mycobacterial infection%Pulmonary/immunology%CD4-positive T-cells%Malnutrition
目的：探讨外周血CD4＋T淋巴细胞对非结核分枝杆菌（NTM）肺病患者营养状况的影响。方法：回顾性调查分析2008年1月至2012年12月期间在我院收治确诊的NTM肺病患者78例，分为细胞免疫功能低下组43例和正常组35例。探讨细胞免疫功能与营养指标相关性。结果：外周血CD4＋与CD3＋、CD8＋T淋巴细胞、CD4＋/CD8＋T淋巴细胞比值（2．03±0．87）呈正相关（P＜0．05）。与ALB、PA无相关性（P＞0．05）。细胞免疫功能低下组外周血淋巴细胞（TLC）计数明显低于对照组，合并支气管扩张例数明显高于对照组，差异有统计学意义（P＜0．05）。结论：NTM患者多伴有营养不良，细胞免疫功能低下的NTM患者合并支气管扩张多见，TLC减少明显，但CD4＋T淋巴细胞与血清蛋白质（ALB＋PA）水平无必然相关性，NTM患者病变的严重程度是基础病变与细胞免疫、营养和感染等因素的共同结果。
目的：探討外週血CD4＋T淋巴細胞對非結覈分枝桿菌（NTM）肺病患者營養狀況的影響。方法：迴顧性調查分析2008年1月至2012年12月期間在我院收治確診的NTM肺病患者78例，分為細胞免疫功能低下組43例和正常組35例。探討細胞免疫功能與營養指標相關性。結果：外週血CD4＋與CD3＋、CD8＋T淋巴細胞、CD4＋/CD8＋T淋巴細胞比值（2．03±0．87）呈正相關（P＜0．05）。與ALB、PA無相關性（P＞0．05）。細胞免疫功能低下組外週血淋巴細胞（TLC）計數明顯低于對照組，閤併支氣管擴張例數明顯高于對照組，差異有統計學意義（P＜0．05）。結論：NTM患者多伴有營養不良，細胞免疫功能低下的NTM患者閤併支氣管擴張多見，TLC減少明顯，但CD4＋T淋巴細胞與血清蛋白質（ALB＋PA）水平無必然相關性，NTM患者病變的嚴重程度是基礎病變與細胞免疫、營養和感染等因素的共同結果。
목적：탐토외주혈CD4＋T림파세포대비결핵분지간균（NTM）폐병환자영양상황적영향。방법：회고성조사분석2008년1월지2012년12월기간재아원수치학진적NTM폐병환자78례，분위세포면역공능저하조43례화정상조35례。탐토세포면역공능여영양지표상관성。결과：외주혈CD4＋여CD3＋、CD8＋T림파세포、CD4＋/CD8＋T림파세포비치（2．03±0．87）정정상관（P＜0．05）。여ALB、PA무상관성（P＞0．05）。세포면역공능저하조외주혈림파세포（TLC）계수명현저우대조조，합병지기관확장례수명현고우대조조，차이유통계학의의（P＜0．05）。결론：NTM환자다반유영양불량，세포면역공능저하적NTM환자합병지기관확장다견，TLC감소명현，단CD4＋T림파세포여혈청단백질（ALB＋PA）수평무필연상관성，NTM환자병변적엄중정도시기출병변여세포면역、영양화감염등인소적공동결과。
Objective To explore the impact of peripheral blood CD4 + T cells on nutritional status of patients with non-tuberculosis mycobacteria (NTM) lung disease. Methods A retrospective analysis was performed including 78 patients with NTM lung disease from January 2008 to December 2012 in Guangzhou Chest Hospital, who were divided into cellular immunocompromised group with 43 cases and control group including 35 cases and then the impact of malnutrition on cellular immune function decline was explored. Results Peripheral blood CD4+T cells were positively correlated with CD3+T cells, CD8+T cells, CD4+/CD8+T cell ratio in all of the included patients(P<0.05), while there was no correlation among peripheral blood CD4+T cells, ALB and PA (P>0.05). Compared with those in control group, TLC count was obviously lower while there were more patients with bronchiectasis in cellular immunocompromised group, which indicated statistical significance (P < 0.05). Conclusions Most of NTM patients are associated with malnutrition and NTM patients of cellular immunocompromised are associated with bronchiectasis easily and obvious reducing of TLC, but CD4+T cells and serum proteins levels are not necessarily correlated. The severity of NTM is commonly caused by such factors as basic pathologic change, cellular immunization, nutrition and infection.
