CAJ | 학술논문

目的：探讨生长抑素（SST）对猪体外循环（CPB）急性期TNF-α、IL-6及IL-10的影响。方法：选取健康家猪24只，随机分为对照组（SS00组）、给予SST剂量5μg/kg（SS05组）、10μg/kg（SS10组）及20μg/kg （SS20组）；各组均行体外循环阻断45 min。于CPB前15 min（T0）、CPB结束时（T1）、术后2 h（T2）、4 h（T3）及6 h（T4）抽取动脉血，以检测TNF-α、IL-6及IL-10水平并比较分析。结果：各组CPB后TNF-α、IL-6、IL-10水平均较T0时显著升高（P＜0．05）；在T1～T4时，SS10与SS20组TNF-α及IL-6水平低于SS00组（P＜0．05），而IL-10水平则高于SS00组（P＜0．05）。结论：CPB开始前给予一定剂量的SST能够减轻体外循环急性期炎症反应；SST应用于CPB中不影响手术安全性。
목적：탐토생장억소（SST）대저체외순배（CPB）급성기TNF-α、IL-6급IL-10적영향。방법：선취건강가저24지，수궤분위대조조（SS00조）、급여SST제량5μg/kg（SS05조）、10μg/kg（SS10조）급20μg/kg （SS20조）；각조균행체외순배조단45 min。우CPB전15 min（T0）、CPB결속시（T1）、술후2 h（T2）、4 h（T3）급6 h（T4）추취동맥혈，이검측TNF-α、IL-6급IL-10수평병비교분석。결과：각조CPB후TNF-α、IL-6、IL-10수평균교T0시현저승고（P＜0．05）；재T1～T4시，SS10여SS20조TNF-α급IL-6수평저우SS00조（P＜0．05），이IL-10수평칙고우SS00조（P＜0．05）。결론：CPB개시전급여일정제량적SST능구감경체외순배급성기염증반응；SST응용우CPB중불영향수술안전성。
Objective To investigate the effects of somatostatin (SST) on levels of IL-6,IL-8 and TNF-αduring CPB in pigs. Methods Twenty four healthy pigs were randomly divided into control group (SS00) and 3 experimental groups, SS05, SS10 and SS20. All pigs were performed by CPB for cardiac arrest in 45 min. the levels of IL-6, IL-10 and TNF-αwere tested and compared. Results The TNF-α, IL-6 and IL-10 levels were higher than T0 among all groups after CPB(P<0.05);The levels of TNF-αand IL-6 after CPB in SS10, SS20 groups were lower than SS00 group(P<0.05), and the IL-10 level was higher(P<0.05). Conclusion Infusing with a certain dose of SST before CPB could down-regulate acute inflammatory response;SST has no impact on the operative safety.