CAJ | 학술논문

目的：研究JWA在急性髓系白血病（AML）患者白血病细胞中的表达，评价其在AML发生、发展及疾病转归中的作用。方法：观察22例AML患者的治疗转归情况，并检测其在初发时及完全缓解后 JWA在RNA及蛋白质水平的表达水平。结果：在RNA及蛋白质水平，AML患者细胞中均有JWA的表达。 JWA蛋白在初发AML患者细胞中表达高，达完全缓解后，表达下降（P＜0．05）。 JWA的表达水平与AML的治疗转归：JWA表达水平较高患者的完全缓解率（87．5％）与表达水平较低患者的完全缓解率相近（83．3％），表达水平较高的患者1疗程完全缓解率（31．25％）要低于表达较低的患者（66．7％），表达水平较高的患者早期复发率（42．86％）则高于表达较低的患者（20．00％）。结论：JWA可能参与了AML的发生，JWA表达增高可能是AML难治复发的原因之一。
목적：연구JWA재급성수계백혈병（AML）환자백혈병세포중적표체，평개기재AML발생、발전급질병전귀중적작용。방법：관찰22례AML환자적치료전귀정황，병검측기재초발시급완전완해후 JWA재RNA급단백질수평적표체수평。결과：재RNA급단백질수평，AML환자세포중균유JWA적표체。 JWA단백재초발AML환자세포중표체고，체완전완해후，표체하강（P＜0．05）。 JWA적표체수평여AML적치료전귀：JWA표체수평교고환자적완전완해솔（87．5％）여표체수평교저환자적완전완해솔상근（83．3％），표체수평교고적환자1료정완전완해솔（31．25％）요저우표체교저적환자（66．7％），표체수평교고적환자조기복발솔（42．86％）칙고우표체교저적환자（20．00％）。결론：JWA가능삼여료AML적발생，JWA표체증고가능시AML난치복발적원인지일。
Objective To investigate the expression and significance of JWA in Acute Myeloid Leukemia (AML). Methods Bone marrow mononuclear cell specimens were taken from 22 AML patients in newly diagnosis stage and complete remission stage respectively , and the JWA expression were detected at RNA and protein level. Results (1) JWA was expressed in all the samples at RNA and protein level. (2) At protein level, JWA expression was higher in the cells from newly diagnosed AML patients than in those from patients in complete remission stage (P < 0.05). (3)The complete remission rate of patients with higher expression level of JWA (87.5%) was similar to those with lower expression (83.3%). The complete remission rate of patients with higher expression level of JWA after the first course (31.25%) was lower than those with lower expression (66.7%). The early recurrence rate of patients with higher expression level of JWA (42.86%) was higher than those with lower expression (20%). Conclusion JWA may play an important role in the development and progression of AML. Increased expression of JWA may be one of the causes of refractory and relapsed AML.