CAJ | 학술논문

目的：探讨乙型肝炎病毒及幽门螺杆菌感染对慢性乙型肝炎患者胃粘膜病情变化的影响。方法：对60例感染慢性乙型肝炎病毒的感染者用酶联免疫吸附法（ ELISA ）检测血清中乙型肝炎病毒表面抗原和乙型肝炎病毒核心抗原及幽门螺旋杆菌抗原；免疫组织化学法（ Envision ）检测胃粘膜组织中三者抗原，同时联合快速尿素酶。分为慢性乙型肝炎组和肝硬化组两组，每组30例，肝硬化组再分为食管静脉曲张组和无食管静脉曲张组，每组15例。同时选择30例无肝病的胃炎患者为对照组。结果：29例经胃镜检测发现乙型肝炎病毒，且其中20例患者胃粘膜组织有异常病变，病变主要以中、重度为主，占患者总数的68．97％。31例患者的胃部粘膜组织中组织异常，其炎性病变以轻、中度为主，占70．97％。差别具有统计学意义（ P＜0．05）。慢性乙型肝炎病毒感染者胃粘膜组织中乙肝病毒表面抗原和乙肝病毒核心抗原均为阳性的胃粘膜病变的程度较重。胃粘膜有炎症表达的幽门螺旋杆菌的感染率在慢性乙型肝炎组和肝硬化组分别为77．78％和79．31％，无肝病的胃炎组的感染率为56．70％，各组间无显著性的差别，且差别无统计学意义（ P＞0．05）。结论：乙型肝炎病毒是感染者胃粘膜病变的主要诱因之一，且与胃粘膜病变程度有关；幽门螺旋杆菌感染和慢性乙型肝炎患者胃粘膜病变程度之间无显著关联性。
목적：탐토을형간염병독급유문라간균감염대만성을형간염환자위점막병정변화적영향。방법：대60례감염만성을형간염병독적감염자용매련면역흡부법（ ELISA ）검측혈청중을형간염병독표면항원화을형간염병독핵심항원급유문라선간균항원；면역조직화학법（ Envision ）검측위점막조직중삼자항원，동시연합쾌속뇨소매。분위만성을형간염조화간경화조량조，매조30례，간경화조재분위식관정맥곡장조화무식관정맥곡장조，매조15례。동시선택30례무간병적위염환자위대조조。결과：29례경위경검측발현을형간염병독，차기중20례환자위점막조직유이상병변，병변주요이중、중도위주，점환자총수적68．97％。31례환자적위부점막조직중조직이상，기염성병변이경、중도위주，점70．97％。차별구유통계학의의（ P＜0．05）。만성을형간염병독감염자위점막조직중을간병독표면항원화을간병독핵심항원균위양성적위점막병변적정도교중。위점막유염증표체적유문라선간균적감염솔재만성을형간염조화간경화조분별위77．78％화79．31％，무간병적위염조적감염솔위56．70％，각조간무현저성적차별，차차별무통계학의의（ P＞0．05）。결론：을형간염병독시감염자위점막병변적주요유인지일，차여위점막병변정도유관；유문라선간균감염화만성을형간염환자위점막병변정도지간무현저관련성。
Objective:To analyze the relations between hepatitis B virus markers and helicobacter pylori in patients with hepatitis B virus infection in gastric mucosa, the effect of HBV and helicobacter pylori infection on gastric mucosa in chronic hepatitis B patients .Method:Choose 60 cases patients with chronic HBV infection diagnosed by serum HBV DNA examination .HBV in serum were exterminated with ELISA , while HBsAg and HBcAg and HP-IgG in gastric mucosa were exterminated by immunohistochemistry .Uresase detection , HE, Fuchsin staining and immunohistochemical analysis of helicobacter pylori IgG antigen were conducted .Result:29 cases of gastric mucosa in 60 cases of hepatitis B virus infection in can be detected in hepa-titis B virus, of which 20 patients with gastric tissue abnormalities , inflammatory lesions in the gastric mucosa moderate , se-vere, accounting for 68.97%.31 cases of chronic hepatitis B virus infection in gastric mucosa tissue abnormalities , inflammato-ry lesions with its mild, moderate, accounting for 70.97%.The difference was statistically significant (P <0.05).The degree of chronic hepatitis B virus infection in gastric mucosa surface antigen of hepatitis B virus and hepatitis B virus core antigen -positive patients were heavier gastric lesions .Expression of gastric inflammation in patients with H .pylori infection rate was 77. 78%and 79.31%, respectively , in patients with chronic hepatitis and cirrhosis patients , Helicobacter gastritis patients without liver disease pylori infection rate was 56.70%,There's no significant difference by comparison among groups , the difference has no statistically significant (P>0.05).Conclusion: HBV can be found growing and copying in gastric mucosa , and also be found to be an important factor of gastric mucosa lesions in HBV infection patients;the damage of gastric mucosa with the infec-tion of HBV in the gastric mucosa in the HBV infection patients is of correlation;NO relationship between HBV and Helicobact-er pillories press ions was observed in gastric mucosa , there's no significant association between infection and gastric mucosal lesions in chronic hepatitis B patients of Helicobacter pylori.