中国民康医学
中國民康醫學
중국민강의학
MEDICAL JOURNAL OF CHINSEE PEOPLE HEALTH
2014年
13期
15-17
,共3页
肿瘤标志物%消化道恶性肿瘤%诊断
腫瘤標誌物%消化道噁性腫瘤%診斷
종류표지물%소화도악성종류%진단
Tumor markers%Malignant tumor of digestive tract%Diagnosis
目的：探讨血清肿瘤标志物CEA、AFP、CA199和CA72-4联合检测对消化道系统恶性肿瘤的临床诊断价值。方法：采用电化学发光仪分析110例消化道系统恶性肿瘤患者(恶性肿瘤组),50例消化道良性疾病患者(良性疾病组)与50例健康对照组血清中的CEA、AFP、CA199和CA72-4含量。结果：4种肿瘤标记物在消化道5种恶性肿瘤患者中的含量均高于消化道系统良性疾病组及健康对照组,差异有统计学意义(P<0.01)。消化道良性疾病组和对照组之间差异无统计学意义(P>0.05)。不同的肿瘤标志物对不同的消化道恶性肿瘤检出率不同。在胆囊癌和胰腺癌两种恶性肿瘤中,CA19-9单项与四项指标联合检测的检出率无显著差异(P>0.05)；在直结肠癌中,CEA单项与四项标志物联合检测的检出率也没有显著差异(P>0.05)。结论：血清肿瘤标志物CA72-4、CEA、AFP、CA19-9在不同的消化道恶性肿瘤中其含量不同。因此,针对不同的消化道恶性肿瘤应采用不同的指标联合检测。
目的：探討血清腫瘤標誌物CEA、AFP、CA199和CA72-4聯閤檢測對消化道繫統噁性腫瘤的臨床診斷價值。方法：採用電化學髮光儀分析110例消化道繫統噁性腫瘤患者(噁性腫瘤組),50例消化道良性疾病患者(良性疾病組)與50例健康對照組血清中的CEA、AFP、CA199和CA72-4含量。結果：4種腫瘤標記物在消化道5種噁性腫瘤患者中的含量均高于消化道繫統良性疾病組及健康對照組,差異有統計學意義(P<0.01)。消化道良性疾病組和對照組之間差異無統計學意義(P>0.05)。不同的腫瘤標誌物對不同的消化道噁性腫瘤檢齣率不同。在膽囊癌和胰腺癌兩種噁性腫瘤中,CA19-9單項與四項指標聯閤檢測的檢齣率無顯著差異(P>0.05)；在直結腸癌中,CEA單項與四項標誌物聯閤檢測的檢齣率也沒有顯著差異(P>0.05)。結論：血清腫瘤標誌物CA72-4、CEA、AFP、CA19-9在不同的消化道噁性腫瘤中其含量不同。因此,針對不同的消化道噁性腫瘤應採用不同的指標聯閤檢測。
목적：탐토혈청종류표지물CEA、AFP、CA199화CA72-4연합검측대소화도계통악성종류적림상진단개치。방법：채용전화학발광의분석110례소화도계통악성종류환자(악성종류조),50례소화도량성질병환자(량성질병조)여50례건강대조조혈청중적CEA、AFP、CA199화CA72-4함량。결과：4충종류표기물재소화도5충악성종류환자중적함량균고우소화도계통량성질병조급건강대조조,차이유통계학의의(P<0.01)。소화도량성질병조화대조조지간차이무통계학의의(P>0.05)。불동적종류표지물대불동적소화도악성종류검출솔불동。재담낭암화이선암량충악성종류중,CA19-9단항여사항지표연합검측적검출솔무현저차이(P>0.05)；재직결장암중,CEA단항여사항표지물연합검측적검출솔야몰유현저차이(P>0.05)。결론：혈청종류표지물CA72-4、CEA、AFP、CA19-9재불동적소화도악성종류중기함량불동。인차,침대불동적소화도악성종류응채용불동적지표연합검측。
Objective:To investigate clinical diagnostic value of combined detection of serum tumor markers CEA, AFP, CA199 and CA72-4 in malignant tumors in digestive tract. Methods:The serum CEA, AFP, CA199 and CA72-4 contents in 111 ca-ses with malignant tumors in digestive tract, 50 cases with benign tumors in digestive tract, and 50 healthy controls were analyzed by u-sing electrochemistry luminescence analyzer. Results:The serum CEA, AFP, CA199 and CA72-4 contents in five malignant tumors in digestive tract were higher than those in benign disease in digestive tract group and healthy control group, and the differences were sta-tistically significant (P<0. 01). There were no statistical differences in the serum CEA, AFP, CA199 and CA72-4 contents between benign disease in digestive tract group and healthy control group (P>0. 05). Different malignant tumors in digestive tract had different tumor marker detection rates. In gallbladder carcinoma and pancreatic carcinoma, there were no significant differences in single CA19-9 detection and the combined detection of the four markers (P>0. 05);in colorectal cancer, there were no significant differences in single CEA detection and the combined detection of the four markers (P>0. 05). Conclusions: The serum tumor markers CA72-4, CEA, AFP, CA19-9 contents in the different malignant tumors of digestive tract are different. Therefore, in view of the different ma-lignant tumors of digestive tract, the different combined detection of these markers is used.
