CAJ | 학술논문

目的：分析对比不同化疗方案治疗晚期胃癌老年患者的疗效和安全性。方法：将我院2012年2月至2014年2月收治的60例胃癌晚期老年患者作为研究对象，根据化疗方案的不同分为试验组和对照组，试验组患者给予替吉奥联合奥沙利铂（SOX）治疗，对照组患者接受奥利沙伯、亚叶酸钙和氟尿嘧啶（FOLFOX6）治疗。对比分析两组患者2个周期以上化疗后的疗效。结果：通过化疗，两组的近期有效率和疾病控制率没有显著差别（P＞0．05）；乏力虚弱、胃肠道反应、手足综合征、口腔黏膜炎等不良反应的发生率也没有显著差异（P＞0．05）。结论：试验组的SOX和对照组的FOLFOX6化疗方案在治疗晚期胃癌老年患者时疗效相当，并且不良反应的发生率没有显著差异。
목적：분석대비불동화료방안치료만기위암노년환자적료효화안전성。방법：장아원2012년2월지2014년2월수치적60례위암만기노년환자작위연구대상，근거화료방안적불동분위시험조화대조조，시험조환자급여체길오연합오사리박（SOX）치료，대조조환자접수오리사백、아협산개화불뇨밀정（FOLFOX6）치료。대비분석량조환자2개주기이상화료후적료효。결과：통과화료，량조적근기유효솔화질병공제솔몰유현저차별（P＞0．05）；핍력허약、위장도반응、수족종합정、구강점막염등불량반응적발생솔야몰유현저차이（P＞0．05）。결론：시험조적SOX화대조조적FOLFOX6화료방안재치료만기위암노년환자시료효상당，병차불량반응적발생솔몰유현저차이。
Objective To analyze and compare efficacy and safety of different chemotherapy regimens in the treatment of elderly patients with advanced gastric cancer. Methods 60 elderly patients admitted to our hospital with advanced gastric cancer were selected as research subjects , and divided into experimental group and control group depending on the treatment of chemotherapy. The experimental group were treated with Gio oxaliplatin (SOX), and patients in the control group accepted Olivier Elizabeth, leucovorin and fluorouracil (FOLFOX6) treatment. Compare and analyze the efficacy of the two groups after two cycles of therapy. Results By chemotherapy, recent efficiency and disease control rate were not significantly different (P>0.05) between the two groups;and there was also no significant difference in the incidence of adverse reactions,such as adverse reactions, fatigue weakness, gastrointestinal reactions, hand-foot syndrome, oral mucositis (P > 0.05). Conclusion The efficacy was equivalent between FOLFOX6 chemotherapy SOX test group and the control group in the treatment of elderly patients with advanced gastric , and there was no significant difference in the incidence of adverse reactions.